| Literature DB >> 21438588 |
Aude Langenfeld1, Alain Blond, Sabelle Gueye, Patrick Herson, Bastien Nay, Joëlle Dupont, Soizic Prado.
Abstract
A novel cyclodepsipeptide, iso-isariin B (1), and the known isaridin E (2) were isolated from the entomopathogenic fungus Beauveria felina. Their structures were elucidated using MS/MS fragmentation and extensive 2D-heteronuclear NMR. The X-ray structure of isaridin E was obtained, showing two potent intramolecular H bonds and a type-VI turn with the HyLeu(1)-Pro(2) amide bond in a cis conformation. Iso-isariin B (1) was active against the pest-insect Sitophilus spp. with an LD(50) value of 10 μg/mL. This observation also gives some clues for ecological interpretation of cyclodepsipeptide production by B. felina.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21438588 DOI： 10.1021/np100890n
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050