BACKGROUND: There may be a relationship between cognitive impairment and visual hallucinations (VHs) in patients with Parkinson's disease (PD). The objective of this study was to compare the cognitive profile of hallucinating vs. nonhallucinating patients with Parkinson's disease dementia (PDD). METHODS: The cognitive profile of 86 PDD patients with hallucinations was compared with that of a carefully matched PDD group without hallucinations, all drawn from the baseline assessments of the EXPRESS study with rivastigmine. Logistic regression analysis was employed to identify cognitive measures that have an independent relationship with presence of hallucinations. RESULTS: Worse choice reaction time was the only independent predictor of hallucinations in the logistic regression. A further analysis of the reaction time tasks showed that response selection deficit as opposed to stimulus discrimination deficit was the main difference between the groups. DISCUSSION: These results indicate that attentional control is an important cognitive correlate of VHs in patients with PDD.
BACKGROUND: There may be a relationship between cognitive impairment and visual hallucinations (VHs) in patients with Parkinson's disease (PD). The objective of this study was to compare the cognitive profile of hallucinating vs. nonhallucinating patients with Parkinson's disease dementia (PDD). METHODS: The cognitive profile of 86 PDDpatients with hallucinations was compared with that of a carefully matched PDD group without hallucinations, all drawn from the baseline assessments of the EXPRESS study with rivastigmine. Logistic regression analysis was employed to identify cognitive measures that have an independent relationship with presence of hallucinations. RESULTS: Worse choice reaction time was the only independent predictor of hallucinations in the logistic regression. A further analysis of the reaction time tasks showed that response selection deficit as opposed to stimulus discrimination deficit was the main difference between the groups. DISCUSSION: These results indicate that attentional control is an important cognitive correlate of VHs in patients with PDD.
Authors: Fabrizia D'Antonio; Maddalena Boccia; Antonella Di Vita; Antonio Suppa; Andrea Fabbrini; Marco Canevelli; Francesca Caramia; Marco Fiorelli; Cecilia Guariglia; Stefano Ferracuti; Carlo de Lena; Dag Aarsland; Dominic Ffytche Journal: J Neurol Date: 2022-01-31 Impact factor: 6.682
Authors: Giovanni Albani; Elisa Pedroli; Pietro Cipresso; Daniel Bulla; Veronica Cimolin; Astrid Thomas; Alessandro Mauro; Giuseppe Riva Journal: Parkinsons Dis Date: 2015-05-10
Authors: Xenia Kobeleva; Michael Firbank; Luis Peraza; Peter Gallagher; Alan Thomas; David J Burn; John O'Brien; John-Paul Taylor Journal: Cortex Date: 2017-03-18 Impact factor: 4.027