Literature DB >> 21437755

[Amitriptyline-induced cardiac arrest : treatment with fat emulsion].

V Huge1, H Baschnegger, P Moehnle, A Peraud, J Briegel.   

Abstract

A case of successful resuscitation of a patient with severe amitriptyline intoxication is reported. The measured amitriptyline serum levels far exceeded those assumed to be lethal according to the literature. Resuscitation was successful with the administration of intravenous fat emulsion and the patient recovered without any neurological sequelae.

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Year:  2011        PMID： 21437755     DOI： 10.1007/s00101-011-1848-5

Source DB:  PubMed          Journal:  Anaesthesist        ISSN： 0003-2417            Impact factor:   1.041


  14 in total

1.  Toxicity of tricyclic antidepressants to isolated rat hepatocytes.

Authors:  C O Abernathy; L Lukacs; H J Zimmerman
Journal:  Biochem Pharmacol       Date:  1975-02-01       Impact factor: 5.858

2.  Fatal blood and tissue concentrations of more than 200 drugs.

Authors:  F Musshoff; S Padosch; S Steinborn; B Madea
Journal:  Forensic Sci Int       Date:  2004-06-10       Impact factor: 2.395

3.  Amitriptyline plasma protein binding: effect of plasma pH and relevance to clinical overdose.

Authors:  M A Levitt; J B Sullivan; S M Owens; L Burnham; P R Finley
Journal:  Am J Emerg Med       Date:  1986-03       Impact factor: 2.469

4.  Intravenous fat emulsion to reverse haemodynamic instability from intentional amitriptyline overdose.

Authors:  Paul T Engels; Jonathan S Davidow
Journal:  Resuscitation       Date:  2010-06-01       Impact factor: 5.262

Review 5.  [Lipid emulsion therapy for local anaesthetic toxicity. (LipidRescue)].

Authors:  K Ott
Journal:  Anaesthesist       Date:  2010-06       Impact factor: 1.041

Review 6.  Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies.

Authors:  Chloé Jamaty; Benoit Bailey; Alexandre Larocque; Eric Notebaert; Karine Sanogo; Jean-Marc Chauny
Journal:  Clin Toxicol (Phila)       Date:  2010-01       Impact factor: 4.467

Review 7.  Fatal toxicity of drugs used in psychiatry.

Authors:  Robert J Flanagan
Journal:  Hum Psychopharmacol       Date:  2008-01       Impact factor: 1.672

8.  Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection.

Authors:  Rainer J Litz; Thomas Roessel; Axel R Heller; Sebastian N Stehr
Journal:  Anesth Analg       Date:  2008-05       Impact factor: 5.108

Review 9.  Lipid resuscitation for local anesthetic toxicity: is it really lifesaving?

Authors:  Ulana Leskiw; Guy L Weinberg
Journal:  Curr Opin Anaesthesiol       Date:  2009-10       Impact factor: 2.706

10.  Electrophysiologic effects of imipramine and doxepin on normal and depressed cardiac Purkinje fibers.

Authors:  F J Brennan
Journal:  Am J Cardiol       Date:  1980-10       Impact factor: 2.778
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  2 in total

1.  Amitriptyline-induced ventricular tachycardia: a case report.

Authors:  Khandker Mohammad Nurus Sabah; Abdul Wadud Chowdhury; Mohammad Shahidul Islam; Bishnu Pada Saha; Syed Rezwan Kabir; Shamima Kawser
Journal:  BMC Res Notes       Date:  2017-07-14

2.  Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals.

Authors:  Zofia Tylutki; Aleksander Mendyk; Sebastian Polak
Journal:  J Pharmacokinet Pharmacodyn       Date:  2018-06-25       Impact factor: 2.745
  2 in total

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