BACKGROUND: This study investigated the effect of pediatric vaccination against rotavirus on the number of rotavirus-related hospitalizations of children in Belgium. METHODS: This retrospective database study was conducted at 12 pediatric hospitals in Belgium (546 pediatric beds, 30.6% of Belgian total). Children ≤ 5 years attending hospital for any reason were eligible if they had a rotavirus stool test at one of the study centers. The number of rotavirus-positive stool tests and hospitalizations for acute gastroenteritis (AGE) were compared for prevaccination (June 2004-May 2006) and postvaccination (June 2007-May 2009) study periods. RESULTS: The number of rotavirus-positive stool tests in children who were ≤ 5 years of age decreased from an average of 881 in the prevaccination period to 368 in the first year postvaccination period and 199 in the second. In children 2 to 24 months of age, the percentage reductions were 65% (95% confidence interval [CI]: 62%, 69%) and 80% (95% CI: 77%, 83%) in the first and second years after vaccination, respectively, compared with prevaccination. In children <2 months, the reductions were 50% (95% CI: 36%, 64%) and 64% (95% CI: 49%, 76%), respectively, and in children >24 months the corresponding values were 20% (95% CI: 14%, 28%) and 64% (95% CI: 56%, 72%). The number of AGE-driven hospital admissions and hospitalization days for AGE declined by 33% and 36%, respectively, from prevaccination to the second year postvaccination in children ≤ 2 years of age. CONCLUSIONS: Pediatric rotavirus vaccination in Belgium significantly reduced rotavirus-related hospitalizations in the first and second years after introduction.
BACKGROUND: This study investigated the effect of pediatric vaccination against rotavirus on the number of rotavirus-related hospitalizations of children in Belgium. METHODS: This retrospective database study was conducted at 12 pediatric hospitals in Belgium (546 pediatric beds, 30.6% of Belgian total). Children ≤ 5 years attending hospital for any reason were eligible if they had a rotavirus stool test at one of the study centers. The number of rotavirus-positive stool tests and hospitalizations for acute gastroenteritis (AGE) were compared for prevaccination (June 2004-May 2006) and postvaccination (June 2007-May 2009) study periods. RESULTS: The number of rotavirus-positive stool tests in children who were ≤ 5 years of age decreased from an average of 881 in the prevaccination period to 368 in the first year postvaccination period and 199 in the second. In children 2 to 24 months of age, the percentage reductions were 65% (95% confidence interval [CI]: 62%, 69%) and 80% (95% CI: 77%, 83%) in the first and second years after vaccination, respectively, compared with prevaccination. In children <2 months, the reductions were 50% (95% CI: 36%, 64%) and 64% (95% CI: 49%, 76%), respectively, and in children >24 months the corresponding values were 20% (95% CI: 14%, 28%) and 64% (95% CI: 56%, 72%). The number of AGE-driven hospital admissions and hospitalization days for AGE declined by 33% and 36%, respectively, from prevaccination to the second year postvaccination in children ≤ 2 years of age. CONCLUSIONS: Pediatric rotavirus vaccination in Belgium significantly reduced rotavirus-related hospitalizations in the first and second years after introduction.
Authors: E Anthony S Nelson; Ciro A de Quadros; Mathuram Santosham; Umesh D Parashar; Duncan Steele Journal: Hum Vaccin Immunother Date: 2013-08-16 Impact factor: 3.452
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Authors: V L Rahajamanana; J L Raboba; A Rakotozanany; N J Razafindraibe; E J P R Andriatahirintsoa; A C Razafindrakoto; S A Mioramalala; C Razaiarimanga; G G Weldegebriel; E Burnett; J M Mwenda; M Seheri; M J Mphahlele; A L Robinson Journal: Vaccine Date: 2017-09-25 Impact factor: 3.641
Authors: Marcelino Esparza-Aguilar; Paul A Gastañaduy; Edgar Sánchez-Uribe; Rishi Desai; Umesh D Parashar; Vesta Richardson; Manish Patel Journal: Bull World Health Organ Date: 2013-11-20 Impact factor: 9.408
Authors: Tessa Braeckman; Koen Van Herck; Nadia Meyer; Jean-Yves Pirçon; Montse Soriano-Gabarró; Elisabeth Heylen; Mark Zeller; Myriam Azou; Heidi Capiau; Jan De Koster; Anne-Sophie Maernoudt; Marc Raes; Lutgard Verdonck; Marc Verghote; Anne Vergison; Jelle Matthijnssens; Marc Van Ranst; Pierre Van Damme Journal: BMJ Date: 2012-08-08