Review of vascular leiomyosarcoma and report of a case localized to the greater saphenous vein of the ankle.

Smooth muscle sarcomas involving blood vessels, leiomyosarcomas, are rare, making up less than 2% of all leiomyosarcomas. Leiomyosarcoma of the saphenous vein is even more uncommon, with nearly all cases reported occurring in the thigh. This article reviews leiomyosarcoma of blood vessels and reports on a 62-year-old woman with an extremely rare case of a leiomyosarcoma of the distal portion of the greater saphenous at the ankle.