K Nakamura1, M Nashimoto, K Endoh, M Yamamoto. 1. Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, 951-8510, Niigata City, Japan, kazun@med.niigata-u.ac.jp.
Abstract
OBJECTIVE: Serum 25-hydroxyvitamin D [25(OH)D] is a vitamin D metabolite and a good indicator of vitamin D nutritional status. Low 25(OH)D levels accelerate age-related bone loss in women. The aim of this study was to assess 25(OH)D levels using population-based samples from women in a community in Japan. SUBJECTS AND METHODS: Of all 187 adult women living on a solitary island (Niigata, Japan), 150 (80.2%) were enrolled in a cross-sectional study in early June 1998. After excluding 6 subjects who were undergoing treatment for osteoporosis, 144 female subjects were analyzed. Serum 25(OH)D(2) and 25(OH)D(3) were determined by high-performance liquid chromatography. The sum of 25(OH)D(2) and 25(OH)D(3) was calculated, yielding 25(OH)D, for which a concentration of less than 30 nmol/L was defined as vitamin D insufficiency. Demographic data such as age, height, weight, and body mass index (BMI) were also recorded. RESULTS: The average age of the subjects was 61.3 years (SD 12.8), ranging from 21 to 87. The average concentrations of 25(OH)D(2) and 25(OH)D(3) were 0.5 nmol/L (SD 3.2) and 64.6 nmol/L (SD 17.6), respectively. The number of subjects with 25(OH)D concentration less than 30 nmol/L was 4 of 149 (2.7%). Serum 25(OH)D concentrations were not significantly correlated with age (r=-0.065, p=0.44l) or BMI (r=0.086, p=0.310). CONCLUSION: The present population-based study confirms adequate levels of 25(OH)D and low prevalence of vitamin D insufficiency in Japanese women. Further research should be directed toward darifying which dietary factors determine vitamin D nutrition.
OBJECTIVE: Serum 25-hydroxyvitamin D [25(OH)D] is a vitamin D metabolite and a good indicator of vitamin D nutritional status. Low 25(OH)D levels accelerate age-related bone loss in women. The aim of this study was to assess 25(OH)D levels using population-based samples from women in a community in Japan. SUBJECTS AND METHODS: Of all 187 adult women living on a solitary island (Niigata, Japan), 150 (80.2%) were enrolled in a cross-sectional study in early June 1998. After excluding 6 subjects who were undergoing treatment for osteoporosis, 144 female subjects were analyzed. Serum 25(OH)D(2) and 25(OH)D(3) were determined by high-performance liquid chromatography. The sum of 25(OH)D(2) and 25(OH)D(3) was calculated, yielding 25(OH)D, for which a concentration of less than 30 nmol/L was defined as vitamin Dinsufficiency. Demographic data such as age, height, weight, and body mass index (BMI) were also recorded. RESULTS: The average age of the subjects was 61.3 years (SD 12.8), ranging from 21 to 87. The average concentrations of 25(OH)D(2) and 25(OH)D(3) were 0.5 nmol/L (SD 3.2) and 64.6 nmol/L (SD 17.6), respectively. The number of subjects with 25(OH)D concentration less than 30 nmol/L was 4 of 149 (2.7%). Serum 25(OH)D concentrations were not significantly correlated with age (r=-0.065, p=0.44l) or BMI (r=0.086, p=0.310). CONCLUSION: The present population-based study confirms adequate levels of 25(OH)D and low prevalence of vitamin Dinsufficiency in Japanese women. Further research should be directed toward darifying which dietary factors determine vitamin D nutrition.
Entities:
Keywords:
25-hydroxyvitamin D; Japanese; epidemiology; population-based study; women
Authors: R P van der Wielen; M R Löwik; H van den Berg; L C de Groot; J Haller; O Moreiras; W A van Staveren Journal: Lancet Date: 1995-07-22 Impact factor: 79.321
Authors: T Okano; N Mizuno; S Shida; N Takahashi; T Kobayashi; E Kuroda; S Kodama; T Matsuo Journal: J Nutr Sci Vitaminol (Tokyo) Date: 1981 Impact factor: 2.000
Authors: M E Ooms; P Lips; J C Roos; W J van der Vijgh; C Popp-Snijders; P D Bezemer; L M Bouter Journal: J Bone Miner Res Date: 1995-08 Impact factor: 6.741