Rei Den1, Masahiro Toda, Masako Ohira, Kanehisa Morimoto. 1. Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Abstract
OBJECTS: To determine the changes in salivary chromogranin A (CgA) levels upon awakening in response to of stress by investigating the relationship between salivary CgA levels and the stress response as assessed by GHQ-28 tests. METHODS: The study cohort comprised 40 healthy male university students (age range 19-22 years). Salivary CgA levels were measured at 7:00 a.m. (awakening) and at 7:30, 8:00, and 8:30 a.m. (after awakening). RESULTS: The salivary CgA level was 0.91 ± 0.20 and 0.42 ± 0.1 pmol/ml at 7:00 a.m. in students scoring low (n = 26) and high (n = 14), respectively, on the "severe depression" subscale. This difference in salivary CgA levels at 7:00 between high and low scorers was statistically significant (p < 0.05). CONCLUSIONS: Our findings indicate that depression may influence secretions of salivary CgA via chronic stress-related attenuation of the sympathetic-adrenomedullary system activity.
OBJECTS: To determine the changes in salivary chromogranin A (CgA) levels upon awakening in response to of stress by investigating the relationship between salivary CgA levels and the stress response as assessed by GHQ-28 tests. METHODS: The study cohort comprised 40 healthy male university students (age range 19-22 years). Salivary CgA levels were measured at 7:00 a.m. (awakening) and at 7:30, 8:00, and 8:30 a.m. (after awakening). RESULTS: The salivary CgA level was 0.91 ± 0.20 and 0.42 ± 0.1 pmol/ml at 7:00 a.m. in students scoring low (n = 26) and high (n = 14), respectively, on the "severe depression" subscale. This difference in salivary CgA levels at 7:00 between high and low scorers was statistically significant (p < 0.05). CONCLUSIONS: Our findings indicate that depression may influence secretions of salivary CgA via chronic stress-related attenuation of the sympathetic-adrenomedullary system activity.
Authors: A Schmidt-Reinwald; J C Pruessner; D H Hellhammer; I Federenko; N Rohleder; T H Schürmeyer; C Kirschbaum Journal: Life Sci Date: 1999 Impact factor: 5.037
Authors: C S de Kloet; E Vermetten; C J Heijnen; E Geuze; E G W M Lentjes; H G M Westenberg Journal: Psychoneuroendocrinology Date: 2007-02-12 Impact factor: 4.905