BACKGROUND: The approach to patients with chronic leg ulcers should include not only an accurate diagnosis with appropriate therapy fort he underlying disease, but also the development of effective analgesia. To assess the analgesic effect of topical morphine, we developed a new morphine gel with polihexanide as a preservative for the local pain treatment. PATIENTS AND METHODS: We have studied 30 patients with painful chronic leg ulcers with an average age of 66 years. The respective pain intensity was assessed 24 hours after application of the morphine hydrogel and objectified with a visual analogue scale (VAS) ranged from 0 to 10. RESULTS: All investigated patients had a pain intensity of at least 4 points before the topical application of the morphine gel; the average pain intensity was 7.8. After application of the morphine gel, a significant reduction of the average pain intensity was observed, with an average pain intensity of 4.5. CONCLUSION: These first clinical results with the new morphine gel suggest that at least fort he first 24 hours it combines the advantages of a moist wound healing and a local pain treatment. This new development is certainly a promising therapeutic alternative for pain treatment in patients with chronic leg ulcers.
BACKGROUND: The approach to patients with chronic leg ulcers should include not only an accurate diagnosis with appropriate therapy fort he underlying disease, but also the development of effective analgesia. To assess the analgesic effect of topical morphine, we developed a new morphine gel with polihexanide as a preservative for the local pain treatment. PATIENTS AND METHODS: We have studied 30 patients with painful chronic leg ulcers with an average age of 66 years. The respective pain intensity was assessed 24 hours after application of the morphine hydrogel and objectified with a visual analogue scale (VAS) ranged from 0 to 10. RESULTS: All investigated patients had a pain intensity of at least 4 points before the topical application of the morphine gel; the average pain intensity was 7.8. After application of the morphine gel, a significant reduction of the average pain intensity was observed, with an average pain intensity of 4.5. CONCLUSION: These first clinical results with the new morphine gel suggest that at least fort he first 24 hours it combines the advantages of a moist wound healing and a local pain treatment. This new development is certainly a promising therapeutic alternative for pain treatment in patients with chronic leg ulcers.
Authors: T Hirsch; F Jacobsen; A Rittig; O Goertz; A Niederbichler; H U Steinau; H M Seipp; L Steinstraesser Journal: Hautarzt Date: 2009-12 Impact factor: 0.751
Authors: Tobias Hirsch; Andreas Koerber; Frank Jacobsen; Joachim Dissemond; Hans-Ulrich Steinau; Sören Gatermann; Sammy Al-Benna; Marco Kesting; Hans-Martin Seipp; Lars Steinstraesser Journal: J Surg Res Date: 2009-05-18 Impact factor: 2.192
Authors: Michelle Briggs; Frank D Ferris; Chris Glynn; Keith Harding; Deborah Hofman; Helen Hollinworth; Diane L Krasner; Christina Lindholm; Christine Moffatt; Patricia Price; Marco Romanelli; Gary Sibbald; Mike Stacey; Luc Téot Journal: Nurs Times Date: 2004 Oct 12-18