Literature DB >> 21431128

X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).

Marta Ferraroni1, Carla Bazzicalupi, Anna Rita Bilia, Paola Gratteri.   

Abstract

The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)(2) DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form. © The Royal Society of Chemistry 2011

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Year:  2011        PMID： 21431128     DOI： 10.1039/c1cc10971e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

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4.  Biophysical characterization of the strong stabilization of the RNA triplex poly(U)•poly(A)*poly(U) by 9-O-(ω-amino) alkyl ether berberine analogs.

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Journal:  PLoS One       Date:  2012-05-29       Impact factor: 3.240

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Authors:  Anna Och; Daniel Zalewski; Łukasz Komsta; Przemysław Kołodziej; Janusz Kocki; Anna Bogucka-Kocka
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6.  The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1.

Authors:  Carla Bazzicalupi; Marta Ferraroni; Anna Rita Bilia; Francesca Scheggi; Paola Gratteri
Journal:  Nucleic Acids Res       Date:  2012-10-26       Impact factor: 16.971

7.  Polypharmacology of Berberine Based on Multi-Target Binding Motifs.

Authors:  Ming Chu; Xi Chen; Jing Wang; Likai Guo; Qianqian Wang; Zirui Gao; Jiarui Kang; Mingbo Zhang; Jinqiu Feng; Qi Guo; Binghua Li; Chengrui Zhang; Xueyuan Guo; Zhengyun Chu; Yuedan Wang
Journal:  Front Pharmacol       Date:  2018-07-24       Impact factor: 5.810
  7 in total

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