Modified radiology-guided percutaneous gastrostomy (MRPG) for patients with complete obstruction of the upper digestive tract and who are without endoscopic or nasogastric access.

OBJECTIVE: We wanted to report on our experience with modified radiology-guided percutaneous gastrostomy (MRPG) without endoscopic or nasogastric access for treating patients with complete obstruction of the upper digestive tract.
MATERIALS AND METHODS: Fourteen oncology patients (13 had hypopharyngeal cancer and 1 had upper esophageal cancer) with complete obstruction of the upper digestive tract were recruited. Conventional percutaneous endoscopic gastrostomy (PEG) and radiologic (fluoroscopy-guided) percutaneous gastrostomy (RPG) were not feasible in all the patients. An MRPG technique (with a combination of ultrasound, an air enema and fluoroscopic guidance) was performed in these patients.
RESULTS: We achieved successfully percutaneous gastrostomy using the modified technique in all patients without any major or minor complications after the procedure.
CONCLUSION: A modified radiology-guided percutaneous gastrostomy technique can be safely performed in patients who failed to receive conventional PEG or RPG due to the absence of nasogastric access in the completely obstructed upper digestive tract.

INTRODUCTION

Nutritional support is an essential part in the overall management of patients with head and neck cancer (1). Gastrostomy is often required to provide enteral nutrition in this group of dysphagic patients during combined treatment of chemotherapy and radiotherapy due to an obstructed upper digestive tract (2, 3). Percutaneous endoscopic gastrostomy (PEG) and radiologic percutaneous gastrostomy (RPG) are two currently established methods to provide enteral feeding to this group of patients (4-9). However, PEG is not feasible in patients who have high-grade narrowing or obstruction of the upper digestive tract and this precludes the passage of an endoscope. For conventional fluoroscopy-guided RPG, the stomach is first distended with air introduced via the nasogastric tube. Percutaneous access to the stomach is achieved by the use of fluoroscopy to puncture the gasfilled stomach. In some difficult cases where the esophageal narrowing is tight, a fine bore catheter is introduced via a coaxial guidewire system as a substitute for a nasogastric tube for the purpose of air insufflation. However, in the cases with complete esophageal obstruction that prevents placement of either a nasogastric tube or a guidewire, the percutaneous access to the stomach has to be monitored with a combined approach using ultrasound, an air enema and fluoroscopic guidance.

In this report, we describe a modified combined radiology-guided approach to perform percutaneous gastrostomy in patients with complete obstruction of the upper gastrointestinal tract.

MATERIALS AND METHODS

From December 2005 to June 2010, fourteen patients with complete obstruction of the pharynx or esophagus and who were unable to obtain PEG or conventional fluoroscopy-guided percutaneous gastrostomy underwent modified radiology-guided percutaneous gastrostomy (MRPG). This cohort included two female patients and twelve male patients. The age range was 41-68 years (mean age 49.8 years). Thirteen patients had hypopharyngeal cancers and one had upper thoracic esophageal cancer. The Institutional Review Board of our hospital approved this retrospective study and informed consent was waived due to the retrospective and anonymous nature of the analysis. In this new approach, ultrasound was first performed to outline the margin of the left lobe of the liver. The liver margin was marked on the skin. Then the patients received intravenous administration of 20 mg of hyoscine-N-butylbromide (Buscopan, Boehringer, Ingelheim, Germany). Simultaneously, a fluoroscopically-controlled air enema using 300 mL of room air via the rectum was performed, which outlined the anatomic position of the transverse colon. Next, the position of the collapsed stomach was estimated by the presence of any localized collection of air at the left subdiaphragmatic region. The presumed collapse stomach was then punctured using a 21G fine needle under fluoroscopic guidance with special care to avoid puncturing the liver or transverse colon. The needle was then gradually withdrawn under fluoroscopic control while a small amount of water-soluble contrast medium (Iothalamate meglumine 60%; Conray 60, Mallinckrodt Canada Incorporated, QB, Canada) was continuously injected until the needle tip was confirmed to be within the stomach. Entry of the needle tip within the stomach was recognized when the gastric rugae were opacified by the pooling of contrast medium. The stomach was then insufflated under fluoroscopic control with approximately 600-800 mL of room air through the 21G fine needle (Fig. 1A). After this point, the procedure was similar to what has been described for RPG. In addition to local anesthesia, intravenous sedation with 5 mg midazolam (Dormicum, Roche, Basel, Switzerland) and 50 mg pethidine (Demerol, Roche, Basel, Switzerland) was given to the patients. Gastropexy was performed using two T-fasteners (Cope gastrointestinal suture anchor set; Cook Incorporated, Bloomington, IN). An 18-gauge, 8 cm catheter needle was punctured directly through the gastric wall via a small incised area at the center of the skin between the two gastropexy fasteners. A 100 cm stainless steel guide wire was inserted through the needle and gradual dilation of the tract was carried out by insertion a 14-Fr locking gastrostomy catheter (Wills-Oglesby percutaneous gastrostomy set, Mallinckrodt Institute Modification, Cook Incorporated, Bloomington, IN). Technical success was checked at the end of the procedure with 10 mL of water-soluble contrast medium injected via the pigtail catheter to ensure the gastrostomy catheter was correctly placed within the stomach (Fig. 1B-D). The T-fasteners were cut 14 days after the catheter insertion.

Fig. 1

Modified radiology-guided percutaneous gastrostomy technique.

A. 21G fine needle punctured localized collection of air, which was visible in collapsed stomach under fluoroscopy-guided gastrostomy. Needle tip is then gradually withdrawn while injecting small amounts of water-soluble contrast medium. Location of stomach is confirmed by visualization of opacified gastric rugae. B. Stomach was inflated with approximately 600-800 mL of room air through 21G fine needle. C. 100-cm stainless steel guide wire is inserted through needle, and gastro-percutaneous tract is gradually dilated. D. Insertion of 14-Fr pigtail gastrostomy catheter and injection of small amount of water-soluble contrast medium via pigtail catheter confirmed that gastrostomy catheter is correctly placed within stomach.

RESULTS

Successful insertion of gastrostomy was achieved in all the patients without any procedural complications. An oral diet was successfully started after 24 hours for all the patients. No complications were attributed to the procedure on the 14-, 30- and 60-day follow up.

DISCUSSION

Radiologic percutaneous gastrostomy has been performed since the early 1980s (10-12). Although PEG is a currently acceptable method to construct an enteral access, RPG offers both the highest technical success rate and the lowest cost (13). However, both techniques are not feasible in cancer patients who have high grade narrowing of the oropharynx and/or upper esophagus and for whom endoscopic access or placement of catheter was not possible. In the conventional fluoroscopy-guided RPG, the stomach is directly distended with air by a nasogastric catheter or using the snare method as described by Rosenzweig et al. (14). In our series, gastric insufflation was achieved via a percutaneously placed catheter. To ensure the safety of the puncture, important adjacent structures were outlined using ultrasound (for the outline of liver) and an air enema (for the outline of the transverse colon).

This was our initial experience, and this technique was only applied to patients who had complete upper digestive tract obstruction, loss of nasogastric access and no previous gastric surgery. Anatomic change and the small volume of the gastric remnants will make the procedure more difficult. However, this method can also be applied to those patients with incomplete high grade upper digestive tract obstruction. Although insertion of a nasogastric tube is potentially possible in this group of patients for the purpose of conventional RPG, this new technique can avoid both tumor bleeding and lengthy manipulations to pass the nasogastric tube through the obstructed segment of the digestive tract and provide an alternative approach for the insertion of a feeding gastrostomy tube.

In conclusion, MRPG using combined ultrasound, an air enema and fluoroscopy-guided procedures can be safely, effectively and successfully performed in patients who have complete obstruction of the upper digestive tract without endoscopic or nasogastric access.