Literature DB >> 21430136

NMDA receptor excitotoxicity: impact on phosphatase activity and phosphorylation of huntingtin.

Michael R Jablonski1, Lori Cooper, Dena A Jacob.   

Abstract

Entities:  

Year:  2011        PMID： 21430136      PMCID： PMC6622887          DOI： 10.1523/JNEUROSCI.6747-10.2011

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


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  15 in total

1.  Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.

Authors:  Montserrat Arrasate; Siddhartha Mitra; Erik S Schweitzer; Mark R Segal; Steven Finkbeiner
Journal:  Nature       Date:  2004-10-14       Impact factor: 49.962

Review 2.  Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory.

Authors:  Isabelle M Mansuy; Shirish Shenolikar
Journal:  Trends Neurosci       Date:  2006-11-03       Impact factor: 13.837

3.  Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Authors:  Rona K Graham; Yu Deng; Elizabeth J Slow; Brendan Haigh; Nagat Bissada; Ge Lu; Jacqueline Pearson; Jacqueline Shehadeh; Lisa Bertram; Zoe Murphy; Simon C Warby; Crystal N Doty; Sophie Roy; Cheryl L Wellington; Blair R Leavitt; Lynn A Raymond; Donald W Nicholson; Michael R Hayden
Journal:  Cell       Date:  2006-06-16       Impact factor: 41.582

4.  Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.

Authors:  Simon C Warby; Edmond Y Chan; Martina Metzler; Lu Gan; Roshni R Singaraja; Susan F Crocker; Harold A Robertson; Michael R Hayden
Journal:  Hum Mol Genet       Date:  2005-04-20       Impact factor: 6.150

5.  Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

Authors:  Raúl Pardo; Emilie Colin; Etienne Régulier; Patrick Aebischer; Nicole Déglon; Sandrine Humbert; Frédéric Saudou
Journal:  J Neurosci       Date:  2006-02-01       Impact factor: 6.167

6.  Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.

Authors:  Simon C Warby; Crystal N Doty; Rona K Graham; Jonathan Shively; Roshni R Singaraja; Michael R Hayden
Journal:  Mol Cell Neurosci       Date:  2008-10-18       Impact factor: 4.314

7.  Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

Authors:  Diana Zala; Emilie Colin; Hélène Rangone; Géraldine Liot; Sandrine Humbert; Frédéric Saudou
Journal:  Hum Mol Genet       Date:  2008-09-04       Impact factor: 6.150

8.  The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

Authors:  Sandrine Humbert; Elzbieta A Bryson; Fabrice P Cordelières; Nathan C Connors; Sandeep R Datta; Steven Finkbeiner; Michael E Greenberg; Frédéric Saudou
Journal:  Dev Cell       Date:  2002-06       Impact factor: 12.270

9.  Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.

Authors:  Jeremy M Van Raamsdonk; Jacqueline Pearson; Zoe Murphy; Michael R Hayden; Blair R Leavitt
Journal:  BMC Neurosci       Date:  2006-12-05       Impact factor: 3.288

10.  Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin.

Authors:  Shu-ichi Okamoto; Mahmoud A Pouladi; Maria Talantova; Dongdong Yao; Peng Xia; Dagmar E Ehrnhoefer; Rameez Zaidi; Arjay Clemente; Marcus Kaul; Rona K Graham; Dongxian Zhang; H-S Vincent Chen; Gary Tong; Michael R Hayden; Stuart A Lipton
Journal:  Nat Med       Date:  2009-11-15       Impact factor: 53.440
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  1 in total

1.  Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.

Authors:  Erin E Watkin; Nicolas Arbez; Elaine Waldron-Roby; Robert O'Meally; Tamara Ratovitski; Robert N Cole; Christopher A Ross
Journal:  PLoS One       Date:  2014-02-05       Impact factor: 3.240
  1 in total

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