Literature DB >> 21430125

HGP44 induces protection against Porphyromonas gingivalis-Induced alveolar bone loss in mice.

Kyotaro Muramatsu1, Eitoyo Kokubu, Takahiko Shibahara, Katsuji Okuda, Kazuyuki Ishihara.   

Abstract

The protective effect of DNA vaccines expressing the Arg-gingipain A domain against bone loss induced by Porphyromonas gingivalis infection was investigated in a murine model. phgp44, which expresses the 44-kDa adhesion/hemagglutinin domain of Arg-gingipain A, prevented P. gingivalis-induced alveolar bone loss. The results indicate that phgp44 could be a candidate antigen for a vaccine against P. gingivalis infection.

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Year:  2011        PMID： 21430125      PMCID： PMC3122540          DOI： 10.1128/CVI.00556-10

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  23 in total

Review 1.  Periodontitis: a polymicrobial disruption of host homeostasis.

Authors:  Richard P Darveau
Journal:  Nat Rev Microbiol       Date:  2010-07       Impact factor: 60.633

2.  Porphyromonas gingivalis gingipains and adhesion to epithelial cells.

Authors:  T Chen; K Nakayama; L Belliveau; M J Duncan
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

3.  Arg-gingipain a DNA vaccine induces protective immunity against infection by Porphyromonas gingivalis in a murine model.

Authors:  H Yonezawa; K Ishihara; K Okuda
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

4.  Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1.

Authors:  F C Gibson; C A Genco
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

Review 5.  Molecular genetics of Porphyromonas gingivalis: gingipains and other virulence factors.

Authors:  K Nakayama
Journal:  Curr Protein Pept Sci       Date:  2003-12       Impact factor: 3.272

6.  Antibody responses of periodontitis patients to gingipains of Porphyromonas gingivalis.

Authors:  Satoru Inagaki; Kazuyuki Ishihara; Yuriko Yasaki; Satoru Yamada; Katsuji Okuda
Journal:  J Periodontol       Date:  2003-10       Impact factor: 6.993

Review 7.  Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis.

Authors:  Atsuo Amano; Ichiro Nakagawa; Nobuo Okahashi; Nobushiro Hamada
Journal:  J Periodontal Res       Date:  2004-04       Impact factor: 4.419

8.  Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice.

Authors:  P J Baker; R T Evans; D C Roopenian
Journal:  Arch Oral Biol       Date:  1994-12       Impact factor: 2.633

9.  Passive immunization with monoclonal antibodies against Porphyromonas gingivalis in patients with periodontitis.

Authors:  V Booth; F P Ashley; T Lehner
Journal:  Infect Immun       Date:  1996-02       Impact factor: 3.441

10.  Immunization with Porphyromonas gingivalis capsular polysaccharide prevents P. gingivalis-elicited oral bone loss in a murine model.

Authors:  Dario Gonzalez; Arthur O Tzianabos; Caroline A Genco; Frank C Gibson
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441
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  3 in total

1.  Mucosal immunization with a flagellin-adjuvanted Hgp44 vaccine enhances protective immune responses in a murine Porphyromonas gingivalis infection model.

Authors:  Sao Puth; Seol Hee Hong; Mi Jin Park; Hye Hwa Lee; Youn Suhk Lee; Kwangjoon Jeong; In-Chol Kang; Jeong Tae Koh; Byounggon Moon; Sang Chul Park; Joon Haeng Rhee; Shee Eun Lee
Journal:  Hum Vaccin Immunother       Date:  2017-06-12       Impact factor: 3.452

2.  Immunization with cell-free-generated vaccine protects from Porphyromonas gingivalis-induced alveolar bone loss.

Authors:  Nasi Huang; Elyse Shimomura; Gang Yin; Cuong Tran; Aaron Sato; Alex Steiner; Tyler Heibeck; Michelle Tam; Jeffery Fairman; Frank C Gibson
Journal:  J Clin Periodontol       Date:  2019-01-31       Impact factor: 8.728

Review 3.  Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.

Authors:  Ingar Olsen; Jan Potempa
Journal:  J Oral Microbiol       Date:  2014-08-18       Impact factor: 5.474
  3 in total

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