Literature DB >> 21430052

Persistence of multiple genetic lineages within intrahost populations of Ross River virus.

Wen J Liu1, Michelle F Rourke, Edward C Holmes, John G Aaskov.   

Abstract

We examined the structure and extent of genetic diversity in intrahost populations of Ross River virus (RRV) in samples from six human patients, focusing on the nonstructural (nsP3) and structural (E2) protein genes. Strikingly, although the samples were collected from contrasting ecological settings 3,000 kilometers apart in Australia, we observed multiple viral lineages in four of the six individuals, which is indicative of widespread mixed infections. In addition, a comparison with previously published RRV sequences revealed that these distinct lineages have been in circulation for at least 5 years, and we were able to document their long-term persistence over extensive geographical distances.

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Year:  2011        PMID: 21430052      PMCID: PMC3094999          DOI: 10.1128/JVI.02622-10

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  23 in total

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