| Literature DB >> 21430052 |
Wen J Liu1, Michelle F Rourke, Edward C Holmes, John G Aaskov.
Abstract
We examined the structure and extent of genetic diversity in intrahost populations of Ross River virus (RRV) in samples from six human patients, focusing on the nonstructural (nsP3) and structural (E2) protein genes. Strikingly, although the samples were collected from contrasting ecological settings 3,000 kilometers apart in Australia, we observed multiple viral lineages in four of the six individuals, which is indicative of widespread mixed infections. In addition, a comparison with previously published RRV sequences revealed that these distinct lineages have been in circulation for at least 5 years, and we were able to document their long-term persistence over extensive geographical distances.Entities:
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Year: 2011 PMID: 21430052 PMCID: PMC3094999 DOI: 10.1128/JVI.02622-10
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103