BACKGROUND: Low serum 25-hydroxyvitamin D (25[OH]D) levels are common and may be associated with morbidity and mortality (and indeed with frailty more generally). This association is not restricted to the links between vitamin D and calcium and bone metabolism. OBJECTIVE: To review the influences of vitamin D on the aging process other than those related to bone and calcium. Its effect on mortality is also assessed. METHODS: The PubMed database was searched for English-language articles relating to vitamin D, using the following MeSH terms: vitamin D, mortality, cardiovascular diseases, and frailty. In addition, searches were carried out with Google. RESULTS: Although some of the reported results have proved controversial, overall the evidence seems to support an association between low serum 25[OH]D levels and mortality rates (all-cause and cardiovascular). Frailty is a condition frequently associated with low serum 25[OH]D levels. CONCLUSION: The aging process and mortality are associated with low vitamin D levels. Prospective controlled trials are warranted to determine whether vitamin D supplements can increase longevity and reduce the incidence of certain conditions.
BACKGROUND: Low serum 25-hydroxyvitamin D (25[OH]D) levels are common and may be associated with morbidity and mortality (and indeed with frailty more generally). This association is not restricted to the links between vitamin D and calcium and bone metabolism. OBJECTIVE: To review the influences of vitamin D on the aging process other than those related to bone and calcium. Its effect on mortality is also assessed. METHODS: The PubMed database was searched for English-language articles relating to vitamin D, using the following MeSH terms: vitamin D, mortality, cardiovascular diseases, and frailty. In addition, searches were carried out with Google. RESULTS: Although some of the reported results have proved controversial, overall the evidence seems to support an association between low serum 25[OH]D levels and mortality rates (all-cause and cardiovascular). Frailty is a condition frequently associated with low serum 25[OH]D levels. CONCLUSION: The aging process and mortality are associated with low vitamin D levels. Prospective controlled trials are warranted to determine whether vitamin D supplements can increase longevity and reduce the incidence of certain conditions.
Authors: W N Souza; R Aparicio-Ugarriza; M M Bibiloni; G Palacios; I Aguilar; J A Tur; M González-Gross Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Stefan Pilz; Katharina Kienreich; Daniel Stückler; Andreas Meinitzer; Andreas Tomaschitz Journal: Int J Endocrinol Date: 2012-02-16 Impact factor: 3.257
Authors: Iolanthé M Kruger; Marlena C Kruger; Colleen M Doak; Aletta E Schutte; Hugo W Huisman; Johannes M Van Rooyen; Rudolph Schutte; Leoné Malan; Nicolaas T Malan; Carla M T Fourie; Annamarie Kruger Journal: PLoS One Date: 2013-01-23 Impact factor: 3.240
Authors: Kim Bouillon; Mika Kivimaki; Mark Hamer; Severine Sabia; Eleonor I Fransson; Archana Singh-Manoux; Catharine R Gale; G David Batty Journal: BMC Geriatr Date: 2013-06-21 Impact factor: 3.921