Literature DB >> 21428961

Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?

Martina Schröder1.   

Abstract

Human DDX3 is a DEAD (Asp-Glu-Ala-Asp)-box RNA helicase that appears to be a prime target for viral manipulation. While two viruses that manifest major global health threats, HIV and HCV (hepatitis C virus), utilize DDX3 for their replication, other viruses inhibit DDX3's newly identified function in innate antiviral signalling. This review discusses the role of DDX3 in antiviral immunity and its inhibition or exploitation by different viruses.

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Year:  2011        PMID： 21428961     DOI： 10.1042/BST0390679

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  24 in total

Review 1.  Translation initiation of the HIV-1 mRNA.

Authors:  Théophile Ohlmann; Chloé Mengardi; Marcelo López-Lastra
Journal:  Translation (Austin)       Date:  2014-10-31

2.  The ATP-Dependent RNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Gene Expression.

Authors:  Bita Khadivjam; Camille Stegen; Marc-Aurèle Hogue-Racine; Nabil El Bilali; Katinka Döhner; Beate Sodeik; Roger Lippé
Journal:  J Virol       Date:  2017-03-29       Impact factor: 5.103

Review 3.  Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases.

Authors:  Megha Haridas Upadya; Jude Juventus Aweya; Yee-Joo Tan
Journal:  World J Gastroenterol       Date:  2014-03-21       Impact factor: 5.742

4.  Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection.

Authors:  Véronique Pène; Qisheng Li; Catherine Sodroski; Ching-Sheng Hsu; T Jake Liang
Journal:  J Virol       Date:  2015-03-04       Impact factor: 5.103

5.  Identification of RNA-protein interaction networks involved in the norovirus life cycle.

Authors:  Surender Vashist; Luis Urena; Yasmin Chaudhry; Ian Goodfellow
Journal:  J Virol       Date:  2012-08-29       Impact factor: 5.103

6.  DDX3 acts as a tumor suppressor in colorectal cancer as loss of DDX3 in advanced cancer promotes tumor progression by activating the MAPK pathway.

Authors:  Lin Shen; Jing Zhang; Meng Xu; Ying Zheng; Mo Wang; Suzhen Yang; Bin Qin; Shunle Li; Lei Dong; Fei Dai
Journal:  Int J Biol Sci       Date:  2022-06-06       Impact factor: 10.750

7.  Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.

Authors:  Annalaura Brai; Roberta Fazi; Cristina Tintori; Claudio Zamperini; Francesca Bugli; Maurizio Sanguinetti; Egidio Stigliano; José Esté; Roger Badia; Sandra Franco; Miguel A Martinez; Javier P Martinez; Andreas Meyerhans; Francesco Saladini; Maurizio Zazzi; Anna Garbelli; Giovanni Maga; Maurizio Botta
Journal:  Proc Natl Acad Sci U S A       Date:  2016-04-26       Impact factor: 11.205

8.  SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes.

Authors:  Evelien Middeljans; Xi Wan; Pascal W Jansen; Vikram Sharma; Hendrik G Stunnenberg; Colin Logie
Journal:  PLoS One       Date:  2012-03-19       Impact factor: 3.240

9.  Deciphering novel host-herpesvirus interactions by virion proteomics.

Authors:  Roger Lippé
Journal:  Front Microbiol       Date:  2012-05-28       Impact factor: 5.640

10.  The Cellular Proteins Grb2 and DDX3 Are Increased upon Human Cytomegalovirus Infection and Act in a Proviral Fashion.

Authors:  Yolaine Cavignac; Diana Lieber; Kerstin Laib Sampaio; Johannes Madlung; Tobias Lamkemeyer; Gerhard Jahn; Alfred Nordheim; Christian Sinzger
Journal:  PLoS One       Date:  2015-06-29       Impact factor: 3.240
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