Literature DB >> 21428934

Hepatitis C virus entry and the tetraspanin CD81.

Michelle J Farquhar1, Helen J Harris, Jane A McKeating.   

Abstract

CD81, a member of the tetraspanin integral membrane protein family, has been identified as an essential receptor for HCV (hepatitis C virus). The present review highlights recent published data on the role that CD81 plays in HCV entry, including the importance of actin-dependent lateral diffusion of CD81 within the cell membrane, CD81 endocytosis and the CD81-Claudin-1 receptor complex in HCV internalization. Additional functions for CD81 in the viral life cycle and the role of HCV-CD81 interactions in HCV-induced B-cell and CNS (central nervous system) abnormalities are discussed.

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Year:  2011        PMID： 21428934     DOI： 10.1042/BST0390532

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  18 in total

Review 1.  Unexpected structural features of the hepatitis C virus envelope protein 2 ectodomain.

Authors:  Ali Sabahi; Susan L Uprichard; William C Wimley; Srikanta Dash; Robert F Garry
Journal:  J Virol       Date:  2014-07-02       Impact factor: 5.103

Review 2.  Lipid testing in infectious diseases: possible role in diagnosis and prognosis.

Authors:  Sebastian Filippas-Ntekouan; Evangelos Liberopoulos; Moses Elisaf
Journal:  Infection       Date:  2017-05-08       Impact factor: 3.553

3.  Interactions Between Hepatitis C Virus and Mitochondria: Impact on Pathogenesis and Innate Immunity.

Authors:  Ting Wang; Steven A Weinman
Journal:  Curr Pathobiol Rep       Date:  2013-09

4.  Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.

Authors:  Mohamed Hassan; Denis Selimovic; Abdelouahid El-Khattouti; Hanan Ghozlan; Youssef Haikel; Ola Abdelkader
Journal:  World J Exp Med       Date:  2012-04-20

5.  Tetraspanin CD151 Promotes Initial Events in Human Cytomegalovirus Infection.

Authors:  Daniel Hochdorfer; Luise Florin; Christian Sinzger; Diana Lieber
Journal:  J Virol       Date:  2016-06-24       Impact factor: 5.103

Review 6.  Lipids and HCV.

Authors:  M F Bassendine; D A Sheridan; S H Bridge; D J Felmlee; R D G Neely
Journal:  Semin Immunopathol       Date:  2012-10-31       Impact factor: 9.623

7.  Hepatitis C virus induces epidermal growth factor receptor activation via CD81 binding for viral internalization and entry.

Authors:  Jingyu Diao; Homer Pantua; Hai Ngu; Laszlo Komuves; Lauri Diehl; Gabriele Schaefer; Sharookh B Kapadia
Journal:  J Virol       Date:  2012-08-01       Impact factor: 5.103

8.  CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of hepatitis C virus-infected cells and induction of interferon-alpha.

Authors:  Shuye Zhang; Karen Kodys; Gregory J Babcock; Gyongyi Szabo
Journal:  Hepatology       Date:  2013-01-18       Impact factor: 17.425

Review 9.  New targets for treatment against HCV infection.

Authors:  Qiuwei Pan; Luc J W van der Laan
Journal:  Best Pract Res Clin Gastroenterol       Date:  2012-08       Impact factor: 3.043

10.  Molecular characterization of a tetraspanin from the human liver fluke, Opisthorchis viverrini.

Authors:  Supawadee Piratae; Smarn Tesana; Malcolm K Jones; Paul J Brindley; Alex Loukas; Erica Lovas; Veerachai Eursitthichai; Banchob Sripa; Sirikanda Thanasuwan; Thewarach Laha
Journal:  PLoS Negl Trop Dis       Date:  2012-12-06
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