The immunomodulating activities of resveratrol glucosides in humans.

Numerous data are now available on the beneficial properties of the polyphenolic compound resveratrol (3,5,4'-trihydroxy-stilbene) including its anti-inflammatory, antioxidant and antitumor effects, its role in the aging process and in the prevention of heart and neurodegenerative diseases. In addition, derivatives of resveratrol, including glucosylated molecules, have been linked to similar beneficial effects. The immune response is regulated by networks of complex molecular and cellular interactions: the effects of resveratrol and derivatives, as resveratrol glucosides, in this multifaceted immune system are partially unknown. In this paper, we review patents in which resveratrol glucosides are specifically involved in immunological activity in humans. This article highlights recent patents in which a future usage of resveratrol glucosides is envisaged, as therapeutic agents providing a promising immuno-modulatory approach in regulating immunological and inflammatory responses.