Feng Zhu1, Guanghua Guo. 1. Department of Critical Care Medicine, the First Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, PR China. 13907919783@139.com
Abstract
OBJECTIVE: To review the basic research, the clinical progress, and the mechanism of bone marrow mesenchymal stem cells (BMSCs) in acute lung injury (ALI). METHODS: The literature concerning the basic and clinical researches of BMSCs in ALI was reviewed. RESULTS: BMSCs can take the initiative to "homing" the site of lung injury and take participate in repair by means of differentiation, meanwhile BMSCs could regulate and balance local and systematic inflammatory response and immune disorders in ALI. Currently, the mechanism of BMSCs on anti-inflammation and immune regulation in ALI is not clear. CONCLUSION: BMSCs have comprehensive biological effect on ALI, providing a potential clinical treatment and also laying the foundation for gene therapy and stem cell therapy of ALI in the future.
OBJECTIVE: To review the basic research, the clinical progress, and the mechanism of bone marrow mesenchymal stem cells (BMSCs) in acute lung injury (ALI). METHODS: The literature concerning the basic and clinical researches of BMSCs in ALI was reviewed. RESULTS: BMSCs can take the initiative to "homing" the site of lung injury and take participate in repair by means of differentiation, meanwhile BMSCs could regulate and balance local and systematic inflammatory response and immune disorders in ALI. Currently, the mechanism of BMSCs on anti-inflammation and immune regulation in ALI is not clear. CONCLUSION: BMSCs have comprehensive biological effect on ALI, providing a potential clinical treatment and also laying the foundation for gene therapy and stem cell therapy of ALI in the future.