Literature DB >> 21426288

Life-threatening hypokalaemia associated with ibuprofen-induced renal tubular acidosis.

Jennifer L Ng1, David J R Morgan, Nelson K M Loh, Seng K Gan, Patrick L Coleman, Gregory S Y Ong, David Prentice.   

Abstract

Renal tubular acidosis is an underreported complication of ibuprofen misuse, and can result in life-threatening hypokalaemia. We describe four patients who presented with profound hypokalaemia and muscle weakness associated with excessive ibuprofen ingestion. Ibuprofen cessation and supportive management resulted in complete biochemical resolution within a few days. These cases remind practitioners about potential complications of unmonitored use of over-the-counter analgesics, including those with potential for misuse due to their codeine content.

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Year:  2011        PMID: 21426288     DOI: 10.5694/j.1326-5377.2011.tb02982.x

Source DB:  PubMed          Journal:  Med J Aust        ISSN: 0025-729X            Impact factor:   7.738


  9 in total

Review 1.  Managing acute pain in patients who report lactose intolerance: the safety of an old excipient re-examined.

Authors:  Deanna Mill; Jessica Dawson; Jacinta Lee Johnson
Journal:  Ther Adv Drug Saf       Date:  2018-01-24

2.  Medicines containing codeine: perspectives of medical professionals in the Republic of Ireland.

Authors:  M Foley; T Carney; R Harris; E Fitzpatrick; A Rapca-Veillet; M C Van Hout
Journal:  Ir J Med Sci       Date:  2017-01-09       Impact factor: 1.568

3.  Ibuprofen-related renal tubular acidosis in pregnancy.

Authors:  Andrew Mallett; Matthew Lynch; George T John; Helen Healy; Karin Lust
Journal:  Obstet Med       Date:  2011-08-23

4.  Patient adherence to and tolerability of self-administered interferon β-1a using an electronic autoinjection device: a multicentre, open-label, phase IV study.

Authors:  Alessandra Lugaresi; Ciro Florio; Vincenzo Brescia-Morra; Salvatore Cottone; Paolo Bellantonio; Marinella Clerico; Diego Centonze; Antonio Uccelli; Maria di Ioia; Giovanna De Luca; Andrea Marcellusi; Andrea Paolillo
Journal:  BMC Neurol       Date:  2012-03-05       Impact factor: 2.474

5.  Ibuprofen-induced renal tubular acidosis-a rare cause of rhabdomyolysis: a case report.

Authors:  Minh Huan Dang; Samuel Wu; Christopher Sia
Journal:  Oxf Med Case Reports       Date:  2016-08-29

6.  Ibuprofen Abuse-A Case of Rhabdomyolysis, Hypokalemia, and Hypophosphatemia With Drug-Induced Mixed Renal Tubular Acidosis.

Authors:  Shakuntala Patil; Swathi Subramany; Sachin Patil; Pooja Gurram; Manisha Singh; Michelle Krause
Journal:  Kidney Int Rep       Date:  2018-06-08

7.  Ibuprofen-Induced Hypokalemia and Distal Renal Tubular Acidosis: A Patient's Perceptions of Over-the-Counter Medications and Their Adverse Effects.

Authors:  Mark D Salter
Journal:  Case Rep Crit Care       Date:  2013-07-25

8.  Hypokalaemia and Renal Tubular Acidosis due to Abuse of Nurofen Plus.

Authors:  M J Blackstock; A Lee
Journal:  Case Rep Crit Care       Date:  2012-08-29

9.  Ibuprofen Overuse Leading to Life-threatening Hypokalemia Associated with Renal Tubular Acidosis in Two Patients.

Authors:  Nikhila Thammineni; Pradeep R Kathi; Aditi Sharma; Areeba Jawed
Journal:  Cureus       Date:  2019-12-17
  9 in total

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