| Literature DB >> 21424766 |
Kenneth A Iczkowski1, M Scott Lucia.
Abstract
The 5-tier Gleason grading system for prostate cancer, introduced in 1966, has been proven to be one of the main independent predictors of prostate cancer outcome. This review addresses interobserver concordance in Gleason grading; the persistence of grading discrepancies with frequent upgrading from the biopsy to the prostatectomy specimen; the 2005 International Society of Urologic Pathologists' modifications to Gleason grading; the impact of this modified grading on grade migration and outcome prediction; and molecular correlates of cancer morphology. Data from the most recent years are emphasized.Entities:
Mesh:
Year: 2011 PMID: 21424766 DOI: 10.1007/s11934-011-0181-5
Source DB: PubMed Journal: Curr Urol Rep ISSN: 1527-2737 Impact factor: 3.092