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Literature DB >> 21424696

Ghrelin- and serotonin-producing gastric carcinoid.

Eleanor Latta¹, Fabio Rotondo, Lawrence A Leiter, Eva Horvath, Kalman Kovacs.

Abstract

We report the case of a 57-year-old woman with gastric carcinoid. The tumor was surgically removed and immunohistochemical investigation demonstrated a rare combination: ghrelin and serotonin in the cytoplasm of the tumor cells. The functional significance of simultaneous production of ghrelin and serotonin is not clear. It may be that an autocrine/paracrine interaction exists between these two different hormones.

Entities: Chemical Disease Species

Mesh：

Substances：
Ghrelin
Serotonin

Year: 2012 PMID： 21424696 DOI： 10.1007/s12029-011-9275-z

Source DB: PubMed Journal: J Gastrointest Cancer

41 in total

1. GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils.

Authors: N Hattori; T Saito; T Yagyu; B H Jiang; K Kitagawa; C Inagaki
Journal: J Clin Endocrinol Metab Date: 2001-09 Impact factor: 5.958

2. Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia.

Authors: Josè M Garcia; Mariana Garcia-Touza; Rabih A Hijazi; George Taffet; Daniel Epner; Douglas Mann; Roy G Smith; Glenn R Cunningham; Marco Marcelli
Journal: J Clin Endocrinol Metab Date: 2005-02-15 Impact factor: 5.958

3. Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I.

Authors: Hiroshi Iwakura; Kiminori Hosoda; Ryuichiro Doi; Izumi Komoto; Haruo Nishimura; Choel Son; Junji Fujikura; Tsutomu Tomita; Kazuhiko Takaya; Yoshihiro Ogawa; Tatsuya Hayashi; Gen Inoue; Takashi Akamizu; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Masayuki Imamura; Kazuwa Nakao
Journal: J Clin Endocrinol Metab Date: 2002-11 Impact factor: 5.958

Review 4. Ghrelin: a potential therapeutic target for cancer.

Authors: Dimitrios Nikolopoulos; Stamatis Theocharis; Gregory Kouraklis
Journal: Regul Pept Date: 2010-04-09

5. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.

Authors: Y Date; M Kojima; H Hosoda; A Sawaguchi; M S Mondal; T Suganuma; S Matsukura; K Kangawa; M Nakazato
Journal: Endocrinology Date: 2000-11 Impact factor: 4.736

6. Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

Authors: M Kojima; H Hosoda; Y Date; M Nakazato; H Matsuo; K Kangawa
Journal: Nature Date: 1999-12-09 Impact factor: 49.962

7. Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.

Authors: Yu-Cheng Wang; Emerick Gallego-Arteche; Gioia Iezza; Xiaochen Yuan; Mary R Matli; Su-Pin Choo; Marlene B Zuraek; Ravi Gogia; Francis C Lynn; Michael S German; Emily K Bergsland; David B Donner; Robert S Warren; Eric K Nakakura
Journal: Endocr Relat Cancer Date: 2008-11-05 Impact factor: 5.678

Ghrelin- and serotonin-producing gastric carcinoid.

1. GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils.

2. Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia.

3. Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I.

Review 4. Ghrelin: a potential therapeutic target for cancer.

5. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.

6. Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

7. Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.

8. Ghrelin immunoreactive cells in gastric endocrine tumors and their relation to plasma ghrelin concentration.

9. Rab3B immunoexpression in human pituitary adenomas.

10. Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation.

1. Management of gastric carcinoids (neuroendocrine neoplasms).

Review 2. Classification, clinicopathologic features and treatment of gastric neuroendocrine tumors.

Review 3. Malignant presacral ghrelinoma with long-standing hyperghrelinaemia.

Review 4. New Developments in Gastric Neuroendocrine Neoplasms.