OBJECTIVE: Epidemiological evidences indicate that diabetic individuals may have an increased risk of several cancers; however, the relationships between diabetes and risk of cancers of biliary tract or its subsites remain unclear. METHODS: To provide a quantitative assessment of this relationship, we identified studies by a literature search of Medline (from 1 January 1966) and EMBASE (from 1 January 1974), through 31 July 2010, and by searching the reference lists of pertinent articles. Summary relative risks with corresponding 95% confidence intervals were calculated with a random-effect model. RESULTS: Analysis of 21 studies (8 case-control and 13 cohort studies) found that diabetes was associated with an increased risk of biliary tract cancer, compared with no diabetes (summary RRs = 1.43, 95% CI = 1.18-1.72), with significant heterogeneity among studies (p = 0.001). The positive association was also found between diabetes and risk of gallbladder cancer or extrahepatic cholangiocarcinoma, but not cancer of ampulla of Vater. No significant publication bias was found. CONCLUSION: These findings strongly support the link between diabetes and increased risk of cancer of biliary tract and its subsites: gallbladder cancer or extrahepatic cholangiocarcinoma, but not cancer of ampulla of Vater.
OBJECTIVE: Epidemiological evidences indicate that diabetic individuals may have an increased risk of several cancers; however, the relationships between diabetes and risk of cancers of biliary tract or its subsites remain unclear. METHODS: To provide a quantitative assessment of this relationship, we identified studies by a literature search of Medline (from 1 January 1966) and EMBASE (from 1 January 1974), through 31 July 2010, and by searching the reference lists of pertinent articles. Summary relative risks with corresponding 95% confidence intervals were calculated with a random-effect model. RESULTS: Analysis of 21 studies (8 case-control and 13 cohort studies) found that diabetes was associated with an increased risk of biliary tract cancer, compared with no diabetes (summary RRs = 1.43, 95% CI = 1.18-1.72), with significant heterogeneity among studies (p = 0.001). The positive association was also found between diabetes and risk of gallbladder cancer or extrahepatic cholangiocarcinoma, but not cancer of ampulla of Vater. No significant publication bias was found. CONCLUSION: These findings strongly support the link between diabetes and increased risk of cancer of biliary tract and its subsites: gallbladder cancer or extrahepatic cholangiocarcinoma, but not cancer of ampulla of Vater.
Authors: Adedayo A Onitilo; Jessica M Engel; Ingrid Glurich; Rachel V Stankowski; Gail M Williams; Suhail A Doi Journal: Cancer Causes Control Date: 2012-05-03 Impact factor: 2.506
Authors: Zhiwei Liu; Rotana Alsaggaf; Katherine A McGlynn; Lesley A Anderson; Huei-Ting Tsai; Bin Zhu; Yue Zhu; Sam M Mbulaiteye; Shahinaz M Gadalla; Jill Koshiol Journal: Gut Date: 2018-11-17 Impact factor: 23.059
Authors: V Fedirko; A Lukanova; C Bamia; A Trichopolou; E Trepo; U Nöthlings; S Schlesinger; K Aleksandrova; P Boffetta; A Tjønneland; N F Johnsen; K Overvad; G Fagherazzi; A Racine; M C Boutron-Ruault; V Grote; R Kaaks; H Boeing; A Naska; G Adarakis; E Valanou; D Palli; S Sieri; R Tumino; P Vineis; S Panico; H B As Bueno-de-Mesquita; P D Siersema; P H Peeters; E Weiderpass; G Skeie; D Engeset; J R Quirós; R Zamora-Ros; M J Sánchez; P Amiano; J M Huerta; A Barricarte; D Johansen; B Lindkvist; M Sund; M Werner; F Crowe; K T Khaw; P Ferrari; I Romieu; S C Chuang; E Riboli; M Jenab Journal: Ann Oncol Date: 2012-11-02 Impact factor: 32.976