Literature DB >> 21424168

A model of BmK CT in inhibiting glioma cell migration via matrix metalloproteinase-2 from experimental and molecular dynamics simulation study.

Yue-Jun Fu1, Na An, Kok-Gan Chan, Yan-Bo Wu, Shu-Hua Zheng, Ai-Hua Liang.   

Abstract

The significance of BmK CT, a key chlorotoxin-like peptide isolated from the scorpion venom of Buthus martensii Karsch, is a novel blocker of the chloride ion channel and matrix metalloproteinase-2 (MMP-2). Site-directed mutagenesis of BmK CT, wound healing assay, gelatin zymography assay and computational simulation highlight the importance of electrostatic contribution to BmK CT-MMP-2 catalytic domain complex and a model of BmK CT-MMP-2 catalytic domain complex is therefore proposed. This is the first documentation of the structural mechanism of in the inhibition of glioma cell migration by BmK CT and may lead to the molecular design of specific inhibitors of MMP-2.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21424168     DOI： 10.1007/s10529-011-0587-7

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  12 in total

Review 1.  Recent advances in diagnosis and treatment of gliomas using chlorotoxin-based bioconjugates.

Authors:  Yongjun Cheng; Jinhua Zhao; Wenli Qiao; Kai Chen
Journal:  Am J Nucl Med Mol Imaging       Date:  2014-08-15

2.  SPECT imaging and radionuclide therapy of glioma using 131I labeled Buthus martensii Karsch chlorotoxin.

Authors:  Wenli Qiao; Lingzhou Zhao; Shan Wu; Changcun Liu; Lilei Guo; Yan Xing; Jinhua Zhao
Journal:  J Neurooncol       Date:  2017-05-09       Impact factor: 4.130

3.  Recombinantly expressed MeICT, a new toxin from Mesobuthus eupeus scorpion, inhibits glioma cell proliferation and downregulates Annexin A2 and FOXM1 genes.

Authors:  Maryam Shahbazi Gandomkari; Hoda Ayat; Ali Mohammad Ahadi
Journal:  Biotechnol Lett       Date:  2022-05-07       Impact factor: 2.461

4.  pEGFP-N1-mediated BmK CT expression suppresses the migration of glioma.

Authors:  Yuejun Fu; Yanmei Jiao; Na An; Aihua Liang
Journal:  Cytotechnology       Date:  2012-12-15       Impact factor: 2.058

Review 5.  Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion.

Authors:  Lucie Dardevet; Dipti Rani; Tarek Abd El Aziz; Ingrid Bazin; Jean-Marc Sabatier; Mahmoud Fadl; Elisabeth Brambilla; Michel De Waard
Journal:  Toxins (Basel)       Date:  2015-03-27       Impact factor: 4.546

6.  BmK CT enhances the sensitivity of temozolomide-induced apoptosis of malignant glioma U251 cells in vitro through blocking the AKT signaling pathway.

Authors:  Jun Du; Ruijie Wang; Litian Yin; Yuejun Fu; Yuqing Cai; Zhiyun Zhang; Aihua Liang
Journal:  Oncol Lett       Date:  2017-11-24       Impact factor: 2.967

7.  Molecular Characterization and Biodiversity of a Putative Chlorotoxin from the Iranian Yellow Scorpion Odontobuthus doriae

Authors:  Maryam Naderi Soorki; Amir Jalali; Hamid Galehdari
Journal:  Iran Biomed J       Date:  2017-04-18

8.  Quantitative design of regulatory elements based on high-precision strength prediction using artificial neural network.

Authors:  Hailin Meng; Jianfeng Wang; Zhiqiang Xiong; Feng Xu; Guoping Zhao; Yong Wang
Journal:  PLoS One       Date:  2013-04-01       Impact factor: 3.240

9.  Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3β.

Authors:  Yuejun Fu; Yali Zheng; Kok-Gan Chan; Aihua Liang; Fengyun Hu
Journal:  Mol Biol Rep       Date:  2014-02-19       Impact factor: 2.742

10.  Significant expression of a Chinese scorpion peptide, BmK1, in Escherichia coli through promoter engineering and gene dosage strategy.

Authors:  Jianfeng Wang; Zhiqiang Xiong; Yingying Yang; Na Zhao; Yong Wang
Journal:  Biotechnol Appl Biochem       Date:  2014-03-25       Impact factor: 2.431
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.