Literature DB >> 21424008

Primer extension reactions as a tool to uncover folding motifs within complex G-rich sequences: analysis of the human KRAS NHE.

Manikandan Paramasivam1, Susanna Cogoi, Luigi E Xodo.   

Abstract

We employed primer extension reactions to uncover folding motifs in a nuclease hypersensitive element (NHE) with a complex guanine pattern, located in the human KRAS promoter. We also identified and characterized a new G-rich motif of 21 nt capable of forming a parallel G-quadruplex that is disrupted by protein UP1. © The Royal Society of Chemistry 2011

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Year:  2011        PMID： 21424008     DOI： 10.1039/c1cc10269a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

1.  High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation.

Authors:  Abdelaziz Kerkour; Julien Marquevielle; Stefaniia Ivashchenko; Liliya A Yatsunyk; Jean-Louis Mergny; Gilmar F Salgado
Journal:  J Biol Chem       Date:  2017-03-22       Impact factor: 5.157

2.  Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression.

Authors:  Christine E Kaiser; Natalie A Van Ert; Prashansa Agrawal; Reena Chawla; Danzhou Yang; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2017-06-15       Impact factor: 15.419

3.  Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.

Authors:  Hugo Brito; Ana Cláudia Martins; João Lavrado; Eduarda Mendes; Ana Paula Francisco; Sofia A Santos; Stephan A Ohnmacht; Nam-Soon Kim; Cecília M P Rodrigues; Rui Moreira; Stephen Neidle; Pedro M Borralho; Alexandra Paulo
Journal:  PLoS One       Date:  2015-05-29       Impact factor: 3.240

4.  KRAS promoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units.

Authors:  Peter Podbevšek; Janez Plavec
Journal:  Nucleic Acids Res       Date:  2015-12-09       Impact factor: 16.971

5.  Lipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells.

Authors:  S Cogoi; U Jakobsen; E B Pedersen; S Vogel; L E Xodo
Journal:  Sci Rep       Date:  2016-12-08       Impact factor: 4.379

6.  KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.

Authors:  João Lavrado; Hugo Brito; Pedro M Borralho; Stephan A Ohnmacht; Nam-Soon Kim; Clara Leitão; Sílvia Pisco; Mekala Gunaratnam; Cecília M P Rodrigues; Rui Moreira; Stephen Neidle; Alexandra Paulo
Journal:  Sci Rep       Date:  2015-04-08       Impact factor: 4.379

7.  G-Quadruplex DNA and RNA.

Authors:  Danzhou Yang
Journal:  Methods Mol Biol       Date:  2019

8.  KRAS Promoter G-Quadruplexes from Sequences of Different Length: A Physicochemical Study.

Authors:  Federica D'Aria; Bruno Pagano; Luigi Petraccone; Concetta Giancola
Journal:  Int J Mol Sci       Date:  2021-01-05       Impact factor: 5.923

9.  MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice.

Authors:  Susanna Cogoi; Sonia Zorzet; Valentina Rapozzi; Imrich Géci; Erik B Pedersen; Luigi E Xodo
Journal:  Nucleic Acids Res       Date:  2013-03-06       Impact factor: 16.971

10.  The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription.

Authors:  Susanna Cogoi; Annalisa Ferino; Giulia Miglietta; Erik B Pedersen; Luigi E Xodo
Journal:  Nucleic Acids Res       Date:  2018-01-25       Impact factor: 16.971
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