OBJECTIVE: To determine if the metronidazole (MTZ) 2-gm single dose (recommended) is as effective as the 7-day 500 mg twice a day dose (alternative) for treatment of Trichomonas vaginalis (TV) among HIV+ women. METHODS: Phase IV randomized clinical trial; HIV+ women with culture confirmed TV were randomized to treatment arm: MTZ 2-gm single dose or MTZ 500 mg twice a day 7-day dose. All women were given 2-gm MTZ doses to deliver to their sex partners. Women were recultured for TV at a test-of-cure (TOC) visit occurring 6-12 days after treatment completion. TV-negative women at TOC were again recultured at a 3-month visit. Repeat TV infection rates were compared between arms. RESULTS:Two hundred seventy HIV+/TV+ women were enrolled (mean age = 40 years, ±9.4; 92.2% African American). Treatment arms were similar with respect to age, race, CD4 count, viral load, antiretroviral therapy status, site, and loss-to-follow up. Women in the 7-day arm had lower repeat TV infection rates at TOC [8.5% (11 of 130) versus 16.8% (21 of 125) (relative risk: 0.50, 95% confidence interval = 0.25, 1.00; P < 0.05)] and at 3 months [11.0% (8 of 73) versus 24.1% (19 of 79) (relative risk: 0.46, 95% confidence interval = 0.21, 0.98; P = 0.03)] compared with the single-dose arm. CONCLUSIONS: The 7-day MTZ dose was more effective than the single dose for the treatment of TV among HIV+ women.
RCT Entities:
OBJECTIVE: To determine if the metronidazole (MTZ) 2-gm single dose (recommended) is as effective as the 7-day 500 mg twice a day dose (alternative) for treatment of Trichomonas vaginalis (TV) among HIV+ women. METHODS: Phase IV randomized clinical trial; HIV+ women with culture confirmed TV were randomized to treatment arm: MTZ 2-gm single dose or MTZ 500 mg twice a day 7-day dose. All women were given 2-gm MTZ doses to deliver to their sex partners. Women were recultured for TV at a test-of-cure (TOC) visit occurring 6-12 days after treatment completion. TV-negative women at TOC were again recultured at a 3-month visit. Repeat TV infection rates were compared between arms. RESULTS: Two hundred seventy HIV+/TV+ women were enrolled (mean age = 40 years, ±9.4; 92.2% African American). Treatment arms were similar with respect to age, race, CD4 count, viral load, antiretroviral therapy status, site, and loss-to-follow up. Women in the 7-day arm had lower repeat TV infection rates at TOC [8.5% (11 of 130) versus 16.8% (21 of 125) (relative risk: 0.50, 95% confidence interval = 0.25, 1.00; P < 0.05)] and at 3 months [11.0% (8 of 73) versus 24.1% (19 of 79) (relative risk: 0.46, 95% confidence interval = 0.21, 0.98; P = 0.03)] compared with the single-dose arm. CONCLUSIONS: The 7-day MTZ dose was more effective than the single dose for the treatment of TV among HIV+ women.
Authors: Patricia Kissinger; W Evan Secor; Jami S Leichliter; Rebecca A Clark; Norine Schmidt; Erink Curtin; David H Martin Journal: Clin Infect Dis Date: 2008-04-01 Impact factor: 9.079
Authors: Donna J Helms; Debra J Mosure; Carol A Metcalf; John M Douglas; C Kevin Malotte; Sindy M Paul; Thomas A Peterman Journal: Sex Transm Dis Date: 2008-05 Impact factor: 2.830
Authors: Patricia Kissinger; Angela Amedee; Rebecca A Clark; Jeanne Dumestre; Katherine P Theall; Leann Myers; Michael E Hagensee; Thomas A Farley; David H Martin Journal: Sex Transm Dis Date: 2009-01 Impact factor: 2.830
Authors: Megan Gatski; David H Martin; Judy Levison; Leandro Mena; Rebecca A Clark; Mary Murphy; Harold Henderson; Norine Schmidt; Patricia Kissinger Journal: Sex Transm Infect Date: 2011-01-29 Impact factor: 3.519
Authors: Megan Clare Craig-Kuhn; Charleigh Granade; Christina A Muzny; Barbara Van Der Pol; Rebecca Lillis; Stephanie N Taylor; Norine Schmidt; David H Martin; Patricia Kissinger Journal: Sex Transm Dis Date: 2019-05 Impact factor: 2.830
Authors: Jennifer E Balkus; Barbra A Richardson; Vernon Mochache; Vrasha Chohan; Jeannie D Chan; Linnet Masese; Juma Shafi; Jeanne Marrazzo; Carey Farquhar; R Scott McClelland Journal: Sex Transm Dis Date: 2013-06 Impact factor: 2.830
Authors: Patricia Kissinger; Alys Adamski; Rebecca A Clark; Leandro Mena; Judy Levison; David H Martin Journal: Sex Transm Dis Date: 2013-06 Impact factor: 2.830