Literature DB >> 21422985

HIV-1 decreases the levels of neurotrophins in human lymphocytes.

Valeriya Avdoshina1, Alfredo Garzino-Demo, Alessia Bachis, Maria C G Monaco, Pauline M Maki, Rochelle E Tractenberg, Chenglong Liu, Mary A Young, Italo Mocchetti.   

Abstract

Neurotrophins control cell survival. Therefore, we examined whether HIV-1 reduces neurotrophin levels. Serum of HIV-positive individuals exhibited lower concentrations of brain-derived neurotrophic factor (BDNF), but not of other neurotrophins, than HIV-negative individuals. In addition, R5 and X4 strains of HIV-1 decreased BDNF expression in T cells. Our results support the hypothesis that reduced levels of BDNF may be a risk factor for T-cell apoptosis and for neurological complications associated with HIV-1 infection.

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Year:  2011        PMID： 21422985      PMCID： PMC3752340          DOI： 10.1097/QAD.0b013e32834671b3

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  21 in total

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Authors:  H Yamamoto; M E Gurney
Journal:  J Neurosci       Date:  1990-11       Impact factor: 6.167

Review 2.  Neurotrophins and the immune system.

Authors:  José A Vega; Olivia García-Suárez; Jonas Hannestad; Marta Pérez-Pérez; Antonino Germanà
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3.  Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease.

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Review 4.  The Women's Interagency HIV Study: an observational cohort brings clinical sciences to the bench.

Authors:  Melanie C Bacon; Viktor von Wyl; Christine Alden; Gerald Sharp; Esther Robison; Nancy Hessol; Stephen Gange; Yvonne Barranday; Susan Holman; Kathleen Weber; Mary A Young
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5.  A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease.

Authors:  H Kunugi; A Ueki; M Otsuka; K Isse; H Hirasawa; N Kato; T Nabika; S Kobayashi; S Nanko
Journal:  Mol Psychiatry       Date:  2001-01       Impact factor: 15.992

Review 6.  Neurotrophin-regulated signalling pathways.

Authors:  Louis F Reichardt
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-09-29       Impact factor: 6.237

7.  Massive lymphocyte apoptosis in the thymus of functionally deficient TrkB mice.

Authors:  O Garcia-Suarez; M A Blanco-Gelaz; M L Lopez; A Germana; R Cabo; B Díaz-Esnal; I Silos-Santiago; E Ciriaco; J A Vega
Journal:  J Neuroimmunol       Date:  2002-08       Impact factor: 3.478

8.  Expression of mRNA encoding neurotrophins and neurotrophin receptors in rat thymus, spleen tissue and immunocompetent cells. Regulation of neurotrophin-4 mRNA expression by mitogens and leukotriene B4.

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  19 in total

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Review 2.  Implementing neuronal plasticity in NeuroAIDS: the experience of brain-derived neurotrophic factor and other neurotrophic factors.

Authors:  Italo Mocchetti; Alessia Bachis; Lee A Campbell; Valeriya Avdoshina
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3.  Human immunodeficiency virus-associated dementia: a link between accumulation of viral proteins and neuronal degeneration.

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4.  Chronic lithium feeding reduces upregulated brain arachidonic acid metabolism in HIV-1 transgenic rat.

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5.  Human immunodeficiency virus type 1 alters brain-derived neurotrophic factor processing in neurons.

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6.  Single-nucleotide polymorphisms in TrkB and risk for depression: findings from the women's interagency HIV study.

Authors:  Valeriya Avdoshina; Italo Mocchetti; Chenglong Liu; Mary A Young; Kathryn Anastos; Mardge Cohen; Howard Crystal; Celeste L Pearce; Elizabeth T Golub; Rochelle E Tractenberg
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Review 7.  Synaptic dysfunction in human immunodeficiency virus type-1-positive subjects: inflammation or impaired neuronal plasticity?

Authors:  V Avdoshina; A Bachis; I Mocchetti
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Review 8.  Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders.

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9.  Beyond the Brain: The Role of Brain-Derived Neurotrophic Factor in Viroimmune Responses to Antiretroviral Therapy among People Living with HIV with and without Alcohol Use.

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10.  Brain-derived neurotrophic factor (BDNF) is associated with depressive symptoms in older adults with HIV disease.

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Journal:  J Neurovirol       Date:  2020-11-03       Impact factor: 2.643
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