Literature DB >> 2142255

Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets.

K J Martin1, J W Lillie, M R Green.   

Abstract

The adenovirus E1a protein (E1a), a potent transcription activator, contains a transcriptional activating region. Compared with previously described cellular and viral activators, E1a's activating region has unusual structural properties. It seems that E1a's activating region interacts with a cellular target not required for the function of transcriptional activators with 'acidic' activating regions. By contrast, the target of an acidic activating region is required both by acidic activators and by E1a. It is proposed that the cellular target of E1a's activating region is an 'adaptor' that allows E1a to interact with the basic transcriptional machinery.

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Year:  1990        PMID： 2142255     DOI： 10.1038/346147a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  107 in total

1.  Activator-mediated disruption of sequence-specific DNA contacts by the general transcription factor TFIIB.

Authors:  R Evans; J A Fairley; S G Roberts
Journal:  Genes Dev       Date:  2001-11-15       Impact factor: 11.361

2.  The Epstein-Barr virus R transactivator (Rta) contains a complex, potent activation domain with properties different from those of VP16.

Authors:  J M Hardwick; L Tse; N Applegren; J Nicholas; M A Veliuona
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

3.  Sodium butyrate inhibits myogenesis by interfering with the transcriptional activation function of MyoD and myogenin.

Authors:  L A Johnston; S J Tapscott; H Eisen
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

4.  Alternate translation initiation on hepatitis B virus X mRNA produces multiple polypeptides that differentially transactivate class II and III promoters.

Authors:  L Kwee; R Lucito; B Aufiero; R J Schneider
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

5.  Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivation.

Authors:  Jailal N G Ablack; Michael Cohen; Gobi Thillainadesan; Gregory J Fonseca; Peter Pelka; Joe Torchia; Joe S Mymryk
Journal:  J Virol       Date:  2012-05-23       Impact factor: 5.103

6.  Synergistic transcriptional activation by CTF/NF-I and the estrogen receptor involves stabilized interactions with a limiting target factor.

Authors:  E Martinez; Y Dusserre; W Wahli; N Mermod
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

7.  Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.

Authors:  J C Blanco; I M Wang; S Y Tsai; M J Tsai; B W O'Malley; P W Jurutka; M R Haussler; K Ozato
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

8.  A cell-specific factor represses stimulation of transcription in vitro by transcriptional enhancer factor 1.

Authors:  S Chaudhary; C Brou; M E Valentin; N Burton; L Tora; P Chambon; I Davidson
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272

9.  Endogenous expression of E1A in human cells enhances the effect of adenovirus E3 on class I major histocompatibility complex antigen expression.

Authors:  J M Routes; B A Metz; J L Cook
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

10.  Specific mutations in the estrogen receptor change the properties of antiestrogens to full agonists.

Authors:  A Mahfoudi; E Roulet; S Dauvois; M G Parker; W Wahli
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205
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