| Literature DB >> 21420204 |
Mahendra Shiradkar1, John Thomas, Vanita Kanase, Rajendra Dighe.
Abstract
A novel clubbed triazolyl thiophene series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease.Entities:
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Year: 2011 PMID： 21420204 DOI： 10.1016/j.ejmech.2011.02.059
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514