| Literature DB >> 21419990 |
Alfred J Meijer1, Patrice Codogno.
Abstract
Autophagy is inhibited by the mTOR signaling pathway, which is stimulated by increased amino acid levels. When cellular energy production is compromised, AMP-activated protein kinase is activated, mTOR is inhibited and autophagy is stimulated. Two recent studies have shed light on the molecular mechanism by which AMPK controls autophagic flux.Entities:
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Year: 2011 PMID： 21419990 DOI： 10.1016/j.cub.2011.02.007
Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834