| Literature DB >> 21419626 |
Thien-Duc Tran1, David C Pryde, Peter Jones, Fiona M Adam, Neil Benson, Gerwyn Bish, Frederick Calo, Guiseppe Ciaramella, Rachel Dixon, Jonathan Duckworth, David N A Fox, Duncan A Hay, James Hitchin, Nigel Horscroft, Martin Howard, Iain Gardner, Hannah M Jones, Carl Laxton, Tanya Parkinson, Gemma Parsons, Katie Proctor, Mya C Smith, Nicholas Smith, Amy Thomas.
Abstract
The synthesis and structure-activity relationships of a series of novel interferon inducers are described. Pharmacokinetic studies and efficacy assessment of a series of 8-oxo-3-deazapurine analogues led to the identification of compound 33, a potent and selective agonist of the TLR7 receptor with an excellent in vivo efficacy profile in a mouse model.Entities:
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Year: 2011 PMID： 21419626 DOI： 10.1016/j.bmcl.2011.02.092
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823