BACKGROUND: Hereditary spastic paraplegia type 6 (SPG6) is caused by mutations in the NIPA1 gene, this is a rare cause of HSP, until now, all the affected individuals reported displayed "pure" spastic paraplegia. OBJECTIVES: To analyze the genotype/phenotype correlation of mutations so far described in NIPA1. METHODS: Eighty-six Chinese Han HSP patients were investigated for SPG6 mutations by direct sequencing of the NIPA1 gene. RESULTS: One heterozygous missense mutation c.316G>C/p.G106R was identified in a complicated form of ADHSP family with peripheral nerves disease, and SPG6 mutation in our sample accounted for 3.6% (1/28) of ADHSP families and 1.1% (1/86) of non-ARHSP patients who were negative for SPG4, SPG3A and SPG31 mutations. CONCLUSIONS: We report the first complicated case of SPG6 in the world by the presence of peripheral neuropathy, which extends the phenotype initially described.
BACKGROUND:Hereditary spastic paraplegia type 6 (SPG6) is caused by mutations in the NIPA1 gene, this is a rare cause of HSP, until now, all the affected individuals reported displayed "pure" spastic paraplegia. OBJECTIVES: To analyze the genotype/phenotype correlation of mutations so far described in NIPA1. METHODS: Eighty-six Chinese Han HSPpatients were investigated for SPG6 mutations by direct sequencing of the NIPA1 gene. RESULTS: One heterozygous missense mutation c.316G>C/p.G106R was identified in a complicated form of ADHSP family with peripheral nerves disease, and SPG6 mutation in our sample accounted for 3.6% (1/28) of ADHSP families and 1.1% (1/86) of non-ARHSP patients who were negative for SPG4, SPG3A and SPG31 mutations. CONCLUSIONS: We report the first complicated case of SPG6 in the world by the presence of peripheral neuropathy, which extends the phenotype initially described.
Authors: Maria Martinez-Lage; Laura Molina-Porcel; Dana Falcone; Leo McCluskey; Virginia M-Y Lee; Vivianna M Van Deerlin; John Q Trojanowski Journal: Acta Neuropathol Date: 2012-08 Impact factor: 17.088