| Literature DB >> 21419194 |
M A Koike1, F G Garcia, M Kitazawa, K N Green, F M Laferla.
Abstract
The risk of Alzheimer's disease increases following cerebral hypoperfusion. We studied the long-term interaction between low blood flow to the brain and Alzheimer's disease by inducing a transient global ischemic insult in aged 3xTg-AD mice and determining the effects on AD pathology 3-months post injury. We found that global ischemia does not increase the levels of amyloid-β in these mice. However, the injury did lead to enhanced phosphorylation of the amyloid precursor protein (APP) at the Thr668 site in both the 3xTg-AD mice and wild-type controls. Furthermore, we found an increase in insoluble total tau 3-months post-injury. Together these findings further elucidate the long-term impact of cerebral hypoperfusion on Alzheimer's disease.Entities:
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Year: 2011 PMID： 21419194 PMCID： PMC3099741 DOI： 10.1016/j.neulet.2011.03.034
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046