BACKGROUND: Eruptive Spitz naevi have been reported rarely in the literature. In solitary Spitz naevi, BRAF and HRAS mutations, as well as increased copy numbers of chromosome 11p have been identified. OBJECTIVES: To investigate the genetic changes underlying eruptive Spitz naevi. METHODS: We report on a 16-year-old boy who developed multiple disseminated eruptive Spitz naevi within a few months. We analysed BRAF, HRAS, KRAS and NRAS genes in 39 naevi from this patient for hotspot mutations. Furthermore, comparative genomic hybridization analysis was performed in three lesions. RESULTS: None of the Spitz naevi displayed a mutation in the analysed genes, and no chromosomal imbalances were observed. Conclusions Our results indicate that the typical genetic alterations described in solitary Spitz naevi appear to be absent in eruptive Spitz naevi. Yet unknown alternative genetic alterations must account for this rare syndrome.
BACKGROUND: Eruptive Spitz naevi have been reported rarely in the literature. In solitary Spitz naevi, BRAF and HRAS mutations, as well as increased copy numbers of chromosome 11p have been identified. OBJECTIVES: To investigate the genetic changes underlying eruptive Spitz naevi. METHODS: We report on a 16-year-old boy who developed multiple disseminated eruptive Spitz naevi within a few months. We analysed BRAF, HRAS, KRAS and NRAS genes in 39 naevi from this patient for hotspot mutations. Furthermore, comparative genomic hybridization analysis was performed in three lesions. RESULTS: None of the Spitz naevi displayed a mutation in the analysed genes, and no chromosomal imbalances were observed. Conclusions Our results indicate that the typical genetic alterations described in solitary Spitz naevi appear to be absent in eruptive Spitz naevi. Yet unknown alternative genetic alterations must account for this rare syndrome.
Authors: Michael J McConnell; John V Moran; Alexej Abyzov; Schahram Akbarian; Taejeong Bae; Isidro Cortes-Ciriano; Jennifer A Erwin; Liana Fasching; Diane A Flasch; Donald Freed; Javier Ganz; Andrew E Jaffe; Kenneth Y Kwan; Minseok Kwon; Michael A Lodato; Ryan E Mills; Apua C M Paquola; Rachel E Rodin; Chaggai Rosenbluh; Nenad Sestan; Maxwell A Sherman; Joo Heon Shin; Saera Song; Richard E Straub; Jeremy Thorpe; Daniel R Weinberger; Alexander E Urban; Bo Zhou; Fred H Gage; Thomas Lehner; Geetha Senthil; Christopher A Walsh; Andrew Chess; Eric Courchesne; Joseph G Gleeson; Jeffrey M Kidd; Peter J Park; Jonathan Pevsner; Flora M Vaccarino Journal: Science Date: 2017-04-27 Impact factor: 47.728
Authors: Caitlin Porubsky; Jamie K Teer; Yonghong Zhang; Maria Deschaine; Vernon K Sondak; Jane L Messina Journal: J Cutan Pathol Date: 2017-12-17 Impact factor: 1.587
Authors: Thomas Wiesner; Heinz Kutzner; Lorenzo Cerroni; Martin C Mihm; Klaus J Busam; Rajmohan Murali Journal: Pathology Date: 2016-01-18 Impact factor: 5.306