Literature DB >> 2141751

Synaptophysin expression in the striatum in Huntington's disease.

S Goto1, A Hirano.   

Abstract

This immunohistochemical study compares the expression of synaptophysin (SYP) in the striatum in Huntington's disease (HD) with that of calcineurin (CaN), a marker for striatal medium-sized spinous neurons. As compared to controls, in the HD striatum there was a significant loss of SYP immunoreactivity with residual staining displaying an inhomogeneous pattern, which strikingly resembled that of CaN. Our results may indicate that there is a synaptic loss in the striatum with HD and this is most likely due to loss of medium-sized spinous neurons characteristic of this disease.

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Year:  1990        PMID： 2141751     DOI： 10.1007/bf00294227

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  14 in total

1.  Immunohistochemical visualization of afferent nerve terminals in human globus pallidus and its alteration in neostriatal neurodegenerative disorders.

Authors:  S Goto; A Hirano; R R Rojas-Corona
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

2.  Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease.

Authors:  G A Graveland; R S Williams; M DiFiglia
Journal:  Science       Date:  1985-02-15       Impact factor: 47.728

Review 3.  Synapses of identified neurons in the neostriatum.

Authors:  J P Bolam
Journal:  Ciba Found Symp       Date:  1984

4.  Ramifications of the globus pallidus in the rat as indicated by patterns of immunohistochemistry.

Authors:  S N Haber; W J Nauta
Journal:  Neuroscience       Date:  1983-06       Impact factor: 3.590

5.  Calcineurin immunoreactivity in striatonigral degeneration.

Authors:  S Goto; A Hirano; R R Rojas-Corona
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

6.  An immunohistochemical investigation of the human neostriatum in Huntington's disease.

Authors:  S Goto; A Hirano; R R Rojas-Corona
Journal:  Ann Neurol       Date:  1989-03       Impact factor: 10.422

7.  A comparative immunocytochemical study of human cerebellar cortex in X-chromosome-linked copper malabsorption (Menkes' kinky hair disease) and granule cell type cerebellar degeneration.

Authors:  S Goto; A Hirano; R R Rojas-Corona
Journal:  Neuropathol Appl Neurobiol       Date:  1989 Sep-Oct       Impact factor: 8.090

8.  Neuropathological classification of Huntington's disease.

Authors:  J P Vonsattel; R H Myers; T J Stevens; R J Ferrante; E D Bird; E P Richardson
Journal:  J Neuropathol Exp Neurol       Date:  1985-11       Impact factor: 3.685

9.  Loss of matrix calcium-binding protein-containing neurons in Huntington's disease.

Authors:  A Seto-Ohshima; P C Emson; E Lawson; C Q Mountjoy; L H Carrasco
Journal:  Lancet       Date:  1988-06-04       Impact factor: 79.321

10.  Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells.

Authors:  F Navone; R Jahn; G Di Gioia; H Stukenbrok; P Greengard; P De Camilli
Journal:  J Cell Biol       Date:  1986-12       Impact factor: 10.539
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  12 in total

1.  Sex-dependent behavioral impairments in the HdhQ350/+ mouse line.

Authors:  Jessica K Cao; Peter J Detloff; Richard G Gardner; Nephi Stella
Journal:  Behav Brain Res       Date:  2017-09-18       Impact factor: 3.332

2.  Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington's disease mouse model.

Authors:  Tara E Wood; Joshua Barry; Zhenquin Yang; Carlos Cepeda; Michael S Levine; Michelle Gray
Journal:  Hum Mol Genet       Date:  2019-02-01       Impact factor: 6.150

3.  Age-related synapse loss in hippocampal CA3 is not reversed by caloric restriction.

Authors:  M M Adams; H S Donohue; M C Linville; E A Iversen; I G Newton; J K Brunso-Bechtold
Journal:  Neuroscience       Date:  2010-09-18       Impact factor: 3.590

4.  Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats.

Authors:  T D Smith; M M Adams; M Gallagher; J H Morrison; P R Rapp
Journal:  J Neurosci       Date:  2000-09-01       Impact factor: 6.167

5.  Abnormal isoform of prion proteins accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt-Jakob disease.

Authors:  T Kitamoto; R W Shin; K Doh-ura; N Tomokane; M Miyazono; T Muramoto; J Tateishi
Journal:  Am J Pathol       Date:  1992-06       Impact factor: 4.307

6.  Compartmentalization of excitatory amino acid receptors in human striatum.

Authors:  L S Dure; A B Young; J B Penney
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

7.  Distinct neuronal subset reveals perikaryal immunostaining for synaptophysin (protein p38) in the striatum of rats.

Authors:  S Goto; K Korematsu; S Nagahiro; Y Ushio
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

8.  A morphometric and immunohistochemical study of the vestibular nuclear complex in bovine spongiform encephalopathy.

Authors:  M Jeffrey; W G Halliday; C M Goodsir
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

9.  PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.

Authors:  Joseph Ochaba; Alex Mas Monteys; Jacqueline G O'Rourke; Jack C Reidling; Joan S Steffan; Beverly L Davidson; Leslie M Thompson
Journal:  Neuron       Date:  2016-04-14       Impact factor: 17.173

10.  Striatal synaptosomes from Hdh140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation.

Authors:  Antonio Valencia; Ellen Sapp; Jeffrey S Kimm; Hollis McClory; Kwadwo A Ansong; George Yohrling; Seung Kwak; Kimberly B Kegel; Karin M Green; Scott A Shaffer; Neil Aronin; Marian DiFiglia
Journal:  J Huntingtons Dis       Date:  2013
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