[Diabetic cardiomyopathy].

Diabetic cardiomyopathy is characterized by myocardial hypertrophy and fibrosis independent of hypertension, coronary artery disease or other idiopathic heart diseases. The underlying mechanisms of diabetic cardiomyopathy are still elusive. Previous studies have highlighted the importance of metabolic disturbances (dysfunction of glucose transporters, increased free fatty acids, abnormal changes in calcium homeostasis, disordered copper metabolism, insulin resistance), myocardial fibrosis (association with hyperglycemia, myocyte apoptosis, increases in angiotensin II , IGF-1, and pro-inflammatory cytokines, changes in matrix metalloproteinases activity etc.), cardiac autonomic neuropathy, and stem cell in the evolution of diabetic cardiomyopathy. The current overview will focus on the recent advance of pathogenesis of diabetic cardiomyopathy and may help to define the pathology of diabetes related heart diseases.