Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization.

Literature DB >> 2141628

Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization.

A Bandeira¹, T Mota-Santos, S Itohara, S Degermann, C Heusser, S Tonegawa, A Coutinho.

Abstract

Using monoclonal antibodies identifying all gamma/delta and alpha/beta T cell receptors in cytofluorometric analysis, we have compared the composition of intestinal intraepithelial lymphocytes (i-IEL) in euthymic and athymic germ-free (GF) and conventional (SPF) mice. The results show a marked influence of microbial colonization in the numbers of single-positive (CD4+ or CD8+) alpha/beta i-IEL, but little effect in the pool size or characteristics of gamma/delta i-IEL. In young athymic mice, virtually no alpha/beta i-IEL are detected, while considerable numbers of gamma/delta i-IEL remain, though reduced in GF animals.

Entities: Gene Species

Mesh：

Substances：

Year: 1990 PMID： 2141628 PMCID： PMC2188170 DOI： 10.1084/jem.172.1.239

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

33 in total

Review 1. Positive selection of gamma delta T cells.

Authors: J J Lafaille; W Haas; A Coutinho; S Tonegawa
Journal: Immunol Today Date: 1990-03

2. Identification of a putative second T-cell receptor.

Authors: M B Brenner; J McLean; D P Dialynas; J L Strominger; J A Smith; F L Owen; J G Seidman; S Ip; F Rosen; M S Krangel
Journal: Nature Date: 1986 Jul 10-16 Impact factor: 49.962

Review 3. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.

Authors: J A Ledbetter; L A Herzenberg
Journal: Immunol Rev Date: 1979 Impact factor: 12.988

4. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

Authors: D P Dialynas; Z S Quan; K A Wall; A Pierres; J Quintáns; M R Loken; M Pierres; F W Fitch
Journal: J Immunol Date: 1983-11 Impact factor: 5.422

5. A monoclonal antibody discriminating between subsets of T and B cells.

Authors: J Bruce; F W Symington; T J McKearn; J Sprent
Journal: J Immunol Date: 1981-12 Impact factor: 5.422

6. The gut-associated lymphoid system: nature and properties of the large dividing cells.

Authors: D Guy-Grand; C Griscelli; P Vassalli
Journal: Eur J Immunol Date: 1974-06 Impact factor: 5.532

7. Analysis of the effector functions of different populations of mucosal lymphocytes.

Authors: D M Parrott; C Tait; S MacKenzie; A M Mowat; M D Davies; H S Micklem
Journal: Ann N Y Acad Sci Date: 1983-06-30 Impact factor: 5.691

8. The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions.

Authors: D Guy-Grand; C Griscelli; P Vassalli
Journal: J Exp Med Date: 1978-12-01 Impact factor: 14.307

9. The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response.

Authors: J B Hay; B B Hobbs
Journal: J Exp Med Date: 1977-01-01 Impact factor: 14.307

10. Effect of recent antigen priming on adoptive immune responses. III. Antigen-induced selective recruitment of subsets of recirculating lymphocytes reactive to H-2 determinants.

Authors: J Sprent; J F Miller
Journal: J Exp Med Date: 1976-03-01 Impact factor: 14.307

82 in total

Review 1. Tissue distribution, antigen specificity and effector functions of gamma delta T cells in human diseases.

Authors: G De Libero
Journal: Springer Semin Immunopathol Date: 2000

2. T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.

Authors: Sung-Gyoo Park; Ramkumar Mathur; Meixiao Long; Namiko Hosh; Liming Hao; Matthew S Hayden; Sankar Ghosh
Journal: Immunity Date: 2010-11-11 Impact factor: 31.745

3. Gut immune maturation depends on colonization with a host-specific microbiota.

Authors: Hachung Chung; Sünje J Pamp; Jonathan A Hill; Neeraj K Surana; Sanna M Edelman; Erin B Troy; Nicola C Reading; Eduardo J Villablanca; Sen Wang; Jorge R Mora; Yoshinori Umesaki; Diane Mathis; Christophe Benoist; David A Relman; Dennis L Kasper
Journal: Cell Date: 2012-06-22 Impact factor: 41.582

4. Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine.

Authors: K J Maloy; A M Mowat; R Zamoyska; I N Crispe
Journal: Immunology Date: 1991-04 Impact factor: 7.397

5. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta.

Authors: A Bandeira; S Itohara; M Bonneville; O Burlen-Defranoux; T Mota-Santos; A Coutinho; S Tonegawa
Journal: Proc Natl Acad Sci U S A Date: 1991-01-01 Impact factor: 11.205

6. Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells.

Authors: H Komano; Y Fujiura; M Kawaguchi; S Matsumoto; Y Hashimoto; S Obana; P Mombaerts; S Tonegawa; H Yamamoto; S Itohara
Journal: Proc Natl Acad Sci U S A Date: 1995-06-20 Impact factor: 11.205

Review 7. Intestinal intraepithelial T lymphocytes. Our T cell horizons are expanding.

Authors: M Nanno; Y Kanamori; H Saito; M Kawaguchi-Miyashita; S Shimada; H Ishikawa
Journal: Immunol Res Date: 1998-08 Impact factor: 2.829

8. Development of CD8 alpha/beta + TCR alpha beta intestinal intraepithelial lymphocytes in athymic nu/nu mice and participation in regional immune responses.

Authors: M Emoto; Y Emoto; S H Kaufmann
Journal: Immunology Date: 1996-08 Impact factor: 7.397

9. Development and cytolytic function of intestinal intraepithelial T lymphocytes in antigen-minimized mice.

Authors: M Kawaguchi-Miyashita; K Shimizu; M Nanno; S Shimada; T Watanabe; Y Koga; Y Matsuoka; H Ishikawa; K Hashimoto; M Ohwaki
Journal: Immunology Date: 1996-10 Impact factor: 7.397

Review 10. The microbiome and regulation of mucosal immunity.

Authors: Andrew J McDermott; Gary B Huffnagle
Journal: Immunology Date: 2014-05 Impact factor: 7.397