| Literature DB >> 21414782 |
Karen A Evans1, Barry G Shearer, David D Wisnoski, Dongchuan Shi, Steven M Sparks, Daniel D Sternbach, Deborah A Winegar, Andrew N Billin, Christy Britt, James M Way, Andrea H Epperly, Lisa M Leesnitzer, Raymond V Merrihew, Robert X Xu, Millard H Lambert, Jian Jin.
Abstract
A series of phenoxyacetic acids as subtype selective and potent hPPARδ partial agonists is described. Many analogues were readily accessible via a single solution-phase synthetic route which resulted in the rapid identification of key structure-activity relationships (SAR), and the discovery of two potent exemplars which were further evaluated in vivo. Details of the SAR, optimization, and in vivo efficacy of this series are presented herein.Entities:
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Year: 2011 PMID： 21414782 DOI： 10.1016/j.bmcl.2011.02.077
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823