| Literature DB >> 21414779 |
John L Buchanan1, John R Newcomb, David P Carney, Stuart C Chaffee, Lilly Chai, Rod Cupples, Linda F Epstein, Paul Gallant, Yan Gu, Jean-Christophe Harmange, Kathy Hodge, Brett E Houk, Xin Huang, Janan Jona, Smriti Joseph, H Toni Jun, Rakesh Kumar, Chun Li, John Lu, Tom Menges, Michael J Morrison, Perry M Novak, Simon van der Plas, Robert Radinsky, Paul E Rose, Satin Sawant, Ji-Rong Sun, Sekhar Surapaneni, Susan M Turci, Keyang Xu, Evelyn Yanez, Huilin Zhao, Xiaotian Zhu.
Abstract
The insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the regulation of cell growth and differentiation, and in protection from apoptosis. IGF-1R has been shown to be an appealing target for the treatment of human cancer. Herein, we report the synthesis, structure-activity relationships (SAR), X-ray cocrystal structure and in vivo tumor study results for a series of 2,4-bis-arylamino-1,3-pyrimidines.Entities:
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Year: 2011 PMID： 21414779 DOI： 10.1016/j.bmcl.2011.02.075
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823