| Literature DB >> 21414663 |
Carolin J Teman1, Sheryl R Tripp, Sherrie L Perkins, Eric J Duncavage.
Abstract
Merkel cell polyomavirus (MCPyV) is a novel polyomavirus that shows a strong association with Merkel cell carcinoma (MCC). Recent studies have demonstrated MCPyV in some cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a malignancy with a similar demographic as MCC. We tested for the presence of MCPyV by PCR and immunohistochemistry in 18 cases of CLL/SLL. Very low-level MCPyV DNA was detected in 33% of CLL/SLL cases by real-time PCR, but only one case demonstrated immunohistochemical positivity for MCPyV. MCPyV was not identified in 17 cases of follicular lymphoma, suggesting either that MCPyV is involved in CLL/SLL pathogenesis or that the immunodeficiency state of CLL/SLL induces low-level MCPyV reactivation.Entities:
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Year: 2011 PMID： 21414663 DOI： 10.1016/j.leukres.2011.01.032
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156