Literature DB >> 21414622

Genome wide association studies of abdominal aortic aneurysms-biological insights and potential translation applications.

Seamus C Harrison1, Michael V Holmes, Obi Agu, Steve E Humphries.   

Abstract

Abdominal aortic aneurysm (AAA) is a complex disease with important environmental risk factors and a heritability of approximately 70%. Genome wide association studies have revolutionised the study of complex disorders and offer the potential for innovative insight into disease pathogenesis and development of individualised therapeutic options. This paper reviews the progress of genome wide association studies in AAA, highlighting novel disease pathways and potential translational applications of genomic discoveries.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 21414622     DOI： 10.1016/j.atherosclerosis.2011.02.045

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  5 in total

1.  Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.

Authors:  Joanne M Murabito; Charles C White; Maryam Kavousi; Yan V Sun; Mary F Feitosa; Vijay Nambi; Claudia Lamina; Arne Schillert; Stefan Coassin; Joshua C Bis; Linda Broer; Dana C Crawford; Nora Franceschini; Ruth Frikke-Schmidt; Margot Haun; Suzanne Holewijn; Jennifer E Huffman; Shih-Jen Hwang; Stefan Kiechl; Barbara Kollerits; May E Montasser; Ilja M Nolte; Megan E Rudock; Andrea Senft; Alexander Teumer; Pim van der Harst; Veronique Vitart; Lindsay L Waite; Andrew R Wood; Christina L Wassel; Devin M Absher; Matthew A Allison; Najaf Amin; Alice Arnold; Folkert W Asselbergs; Yurii Aulchenko; Stefania Bandinelli; Maja Barbalic; Mladen Boban; Kristin Brown-Gentry; David J Couper; Michael H Criqui; Abbas Dehghan; Martin den Heijer; Benjamin Dieplinger; Jingzhong Ding; Marcus Dörr; Christine Espinola-Klein; Stephan B Felix; Luigi Ferrucci; Aaron R Folsom; Gustav Fraedrich; Quince Gibson; Robert Goodloe; Grgo Gunjaca; Meinhard Haltmayer; Gerardo Heiss; Albert Hofman; Arne Kieback; Lambertus A Kiemeney; Ivana Kolcic; Iftikhar J Kullo; Stephen B Kritchevsky; Karl J Lackner; Xiaohui Li; Wolfgang Lieb; Kurt Lohman; Christa Meisinger; David Melzer; Emile R Mohler; Ivana Mudnic; Thomas Mueller; Gerjan Navis; Friedrich Oberhollenzer; Jeffrey W Olin; Jeff O'Connell; Christopher J O'Donnell; Walter Palmas; Brenda W Penninx; Astrid Petersmann; Ozren Polasek; Bruce M Psaty; Barbara Rantner; Ken Rice; Fernando Rivadeneira; Jerome I Rotter; Adrie Seldenrijk; Marietta Stadler; Monika Summerer; Toshiko Tanaka; Anne Tybjaerg-Hansen; Andre G Uitterlinden; Wiek H van Gilst; Sita H Vermeulen; Sarah H Wild; Philipp S Wild; Johann Willeit; Tanja Zeller; Tatijana Zemunik; Lina Zgaga; Themistocles L Assimes; Stefan Blankenberg; Eric Boerwinkle; Harry Campbell; John P Cooke; Jacqueline de Graaf; David Herrington; Sharon L R Kardia; Braxton D Mitchell; Anna Murray; Thomas Münzel; Anne B Newman; Ben A Oostra; Igor Rudan; Alan R Shuldiner; Harold Snieder; Cornelia M van Duijn; Uwe Völker; Alan F Wright; H-Erich Wichmann; James F Wilson; Jacqueline C M Witteman; Yongmei Liu; Caroline Hayward; Ingrid B Borecki; Andreas Ziegler; Kari E North; L Adrienne Cupples; Florian Kronenberg
Journal:  Circ Cardiovasc Genet       Date:  2011-12-23

2.  SEPP1 gene variants and abdominal aortic aneurysm: gene association in relation to metabolic risk factors and peripheral arterial disease coexistence.

Authors:  Ewa Strauss; Grzegorz Oszkinis; Ryszard Staniszewski
Journal:  Sci Rep       Date:  2014-11-14       Impact factor: 4.379

3.  Identification of EGFLAM, SPATC1L and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies.

Authors:  Yoshiji Yamada; Jun Sakuma; Ichiro Takeuchi; Yoshiki Yasukochi; Kimihiko Kato; Mitsutoshi Oguri; Tetsuo Fujimaki; Hideki Horibe; Masaaki Muramatsu; Motoji Sawabe; Yoshinori Fujiwara; Yu Taniguchi; Shuichi Obuchi; Hisashi Kawai; Shoji Shinkai; Seijiro Mori; Tomio Arai; Masashi Tanaka
Journal:  Int J Mol Med       Date:  2017-03-21       Impact factor: 4.101

4.  Association of non-synonymous variants in WIPF3 and LIPA genes with abdominal aortic aneurysm: an autopsy study.

Authors:  Yuko Maeda; Noriko Sato; Makiko Naka-Mieno; Seijiro Mori; Tomio Arai; Masashi Tanaka; Masaaki Muramatsu; Motoji Sawabe
Journal:  J Geriatr Cardiol       Date:  2016-12       Impact factor: 3.327

5.  Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure.

Authors:  Ewa Strauss; Jolanta Tomczak; Ryszard Staniszewski; Grzegorz Oszkinis
Journal:  PLoS One       Date:  2018-09-06       Impact factor: 3.240
  5 in total

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