| Literature DB >> 2141323 |
A Cossarizza1, D Monti, F Dagna-Bricarelli, G Montagnani, C Franceschi.
Abstract
Lymphocyte subpopulations, NK and LAK activities have been studied in blood mononuclear cells from two human fetuses, the first affected by Down's syndrome, the other showing a normal karyotype. Fetuses presented similar subsets, with a scarcity of CD57+ lymphocytes but an appropriate amount of CD16+ and CD56+ cells, while negligible NK activity was detectable. After 18 h of incubation with human recombinant interleukin-2 (rIL-2), significant enhancement of the cytotoxic capability was observed. This stresses the role of IL-2 as a regulatory molecule during the development of the immune system in the human fetus.Entities:
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Year: 1990 PMID： 2141323 DOI： 10.1016/0165-2478(90)90025-l
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685