BACKGROUND: The incidence of thyroid cancer has doubled over the past decade. The reason for this dramatic increase in incidence is controversial. Some investigators have suggested that the increased incidence is because of increased detection of small primary tumors as a result of diagnostic scrutiny. Conversely, some investigators have demonstrated an increased incidence across all tumor sizes, suggesting that other factors may play a role. This study was undertaken to investigate the clinical, pathologic, and molecular changes present in papillary thyroid cancer over a 15-year period during which the incidence of papillary thyroid cancer doubled. METHODS: A total of 628 patients with conventional papillary thyroid cancer and 228 tumor samples from a single institution were analyzed from 1991 to 2005. Time-trend analyses of demographic, clinical, pathologic, and tumor genotype were performed over three 5-year time periods: group I (1991-1995), group II (1996-2000), and group III (2001-2005). RESULTS: The authors found no differences in age, sex, ethnicity, primary tumor size, rate of extrathyroidal invasion, or overall TNM cancer stage among the 3 time groups. The rate of BRAF V600E mutation was significantly higher in group III (88% BRAF V600E positive) as compared with groups I and II (51% and 43%, respectively) (P < .001). The rate of all the common somatic mutations was also significantly higher in group III (92% positive) as compared with groups I and II (68% and 64%, respectively) (P < .002). CONCLUSIONS: The rate of BRAF V600E mutation increased significantly over a 15-year period at the authors' institution. The findings suggest that a higher rate of BRAF mutation in papillary thyroid cancer may contribute to the increasing incidence of thyroid cancer.
BACKGROUND: The incidence of thyroid cancer has doubled over the past decade. The reason for this dramatic increase in incidence is controversial. Some investigators have suggested that the increased incidence is because of increased detection of small primary tumors as a result of diagnostic scrutiny. Conversely, some investigators have demonstrated an increased incidence across all tumor sizes, suggesting that other factors may play a role. This study was undertaken to investigate the clinical, pathologic, and molecular changes present in papillary thyroid cancer over a 15-year period during which the incidence of papillary thyroid cancer doubled. METHODS: A total of 628 patients with conventional papillary thyroid cancer and 228 tumor samples from a single institution were analyzed from 1991 to 2005. Time-trend analyses of demographic, clinical, pathologic, and tumor genotype were performed over three 5-year time periods: group I (1991-1995), group II (1996-2000), and group III (2001-2005). RESULTS: The authors found no differences in age, sex, ethnicity, primary tumor size, rate of extrathyroidal invasion, or overall TNM cancer stage among the 3 time groups. The rate of BRAFV600E mutation was significantly higher in group III (88% BRAFV600E positive) as compared with groups I and II (51% and 43%, respectively) (P < .001). The rate of all the common somatic mutations was also significantly higher in group III (92% positive) as compared with groups I and II (68% and 64%, respectively) (P < .002). CONCLUSIONS: The rate of BRAFV600E mutation increased significantly over a 15-year period at the authors' institution. The findings suggest that a higher rate of BRAF mutation in papillary thyroid cancer may contribute to the increasing incidence of thyroid cancer.
Authors: Electron Kebebew; Julie Weng; Juergen Bauer; Gustavo Ranvier; Orlo H Clark; Quan-Yang Duh; Daniel Shibru; Boris Bastian; Ann Griffin Journal: Ann Surg Date: 2007-09 Impact factor: 12.969
Authors: Simon Grodski; Tani Brown; Stan Sidhu; Anthony Gill; Bruce Robinson; Diana Learoyd; Mark Sywak; Tom Reeve; Leigh Delbridge Journal: Surgery Date: 2008-12 Impact factor: 3.982
Authors: R Michael Tuttle; Yvonne Lukes; Lynn Onstad; Eugeni Lushnikov; Alexander Abrosimov; Vladislav Troshin; Anatoli Tsyb; Scott Davis; Kenneth J Kopecky; Gary Francis Journal: Thyroid Date: 2008-08 Impact factor: 6.568
Authors: William D T Kent; Stephen F Hall; Phillip A Isotalo; Robyn L Houlden; Ralph L George; Patti A Groome Journal: CMAJ Date: 2007-11-20 Impact factor: 8.262
Authors: Z Jason Qian; Michael C Jin; Kara D Meister; Uchechukwu C Megwalu Journal: JAMA Otolaryngol Head Neck Surg Date: 2019-07-01 Impact factor: 6.223
Authors: Ryan J Ellis; Yonghong Wang; Holly S Stevenson; Myriem Boufraqech; Dhaval Patel; Naris Nilubol; Sean Davis; Daniel C Edelman; Maria J Merino; Mei He; Lisa Zhang; Paul S Meltzer; Electron Kebebew Journal: J Clin Endocrinol Metab Date: 2013-12-11 Impact factor: 5.958