Literature DB >> 21411525

The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response.

Stephane Daffis1, Helen M Lazear, Wen Jun Liu, Michelle Audsley, Michael Engle, Alexander A Khromykh, Michael S Diamond.   

Abstract

The host determinants that contribute to attenuation of the naturally occurring nonpathogenic strain of West Nile virus (WNV), the Kunjin strain (WNV(KUN)), remain unknown. Here, we show that compared to a highly pathogenic North American strain, WNV(KUN) exhibited an enhanced sensitivity to the antiviral effects of type I interferon. Our studies establish that the virulence of WNV(KUN) can be restored in cells and mice deficient in specific interferon regulatory factors (IRFs) or the common type I interferon receptor. Thus, WNV(KUN) is attenuated primarily through its enhanced restriction by type I interferon- and IRF-3-dependent mechanisms.

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Year:  2011        PMID： 21411525      PMCID： PMC3094947          DOI： 10.1128/JVI.00232-11

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence.

Authors:  Brian C Keller; Brenda L Fredericksen; Melanie A Samuel; Richard E Mock; Peter W Mason; Michael S Diamond; Michael Gale
Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

2.  Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains.

Authors:  David W C Beasley; Melissa C Whiteman; Shuliu Zhang; Claire Y-H Huang; Bradley S Schneider; Darci R Smith; Gregory D Gromowski; Stephen Higgs; Richard M Kinney; Alan D T Barrett
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

3.  Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival.

Authors:  Melanie A Samuel; Michael S Diamond
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

4.  Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection.

Authors:  Stephane Daffis; Melanie A Samuel; Mehul S Suthar; Brian C Keller; Michael Gale; Michael S Diamond
Journal:  J Virol       Date:  2008-06-18       Impact factor: 5.103

5.  West Nile virus nonstructural protein 1 inhibits TLR3 signal transduction.

Authors:  Jason R Wilson; Paola Florez de Sessions; Megan A Leon; Frank Scholle
Journal:  J Virol       Date:  2008-06-18       Impact factor: 5.103

6.  The relationships between West Nile and Kunjin viruses.

Authors:  J H Scherret; M Poidinger; J S Mackenzie; A K Broom; V Deubel; W I Lipkin; T Briese; E A Gould; R A Hall
Journal:  Emerg Infect Dis       Date:  2001 Jul-Aug       Impact factor: 6.883

7.  Early production of type I interferon during West Nile virus infection: role for lymphoid tissues in IRF3-independent interferon production.

Authors:  Nigel Bourne; Frank Scholle; Maria Carlan Silva; Shannan L Rossi; Nathan Dewsbury; Barbara Judy; Juliana B De Aguiar; Megan A Leon; D Mark Estes; Rafik Fayzulin; Peter W Mason
Journal:  J Virol       Date:  2007-06-13       Impact factor: 5.103

8.  A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus virulence in mice.

Authors:  Wen Jun Liu; Xiang Ju Wang; David C Clark; Mario Lobigs; Roy A Hall; Alexander A Khromykh
Journal:  J Virol       Date:  2006-03       Impact factor: 5.103

9.  West Nile virus envelope protein inhibits dsRNA-induced innate immune responses.

Authors:  Alvaro Arjona; Michel Ledizet; Karen Anthony; Nathalie Bonafé; Yorgo Modis; Terrence Town; Erol Fikrig
Journal:  J Immunol       Date:  2007-12-15       Impact factor: 5.422

10.  Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms.

Authors:  Stephane Daffis; Melanie A Samuel; Brian C Keller; Michael Gale; Michael S Diamond
Journal:  PLoS Pathog       Date:  2007-07-27       Impact factor: 6.823
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  37 in total

Review 1.  Cell-intrinsic innate immune control of West Nile virus infection.

Authors:  Michael S Diamond; Michael Gale
Journal:  Trends Immunol       Date:  2012-06-20       Impact factor: 16.687

2.  Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.

Authors:  Olivia Perwitasari; Hyelim Cho; Michael S Diamond; Michael Gale
Journal:  J Biol Chem       Date:  2011-11-07       Impact factor: 5.157

3.  West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response.

Authors:  Andrea Schuessler; Anneke Funk; Helen M Lazear; Daphne A Cooper; Shessy Torres; Stephane Daffis; Babal Kant Jha; Yutaro Kumagai; Osamu Takeuchi; Paul Hertzog; Robert Silverman; Shizuo Akira; David J Barton; Michael S Diamond; Alexander A Khromykh
Journal:  J Virol       Date:  2012-02-29       Impact factor: 5.103

Review 4.  The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases.

Authors:  Xiao-Jing Zhang; Ding-Sheng Jiang; Hongliang Li
Journal:  Br J Pharmacol       Date:  2015-02-27       Impact factor: 8.739

5.  VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection.

Authors:  Sarah van Tol; Colm Atkins; Preeti Bharaj; Kendra N Johnson; Adam Hage; Alexander N Freiberg; Ricardo Rajsbaum
Journal:  J Virol       Date:  2020-01-06       Impact factor: 5.103

Review 6.  Climate change impacts on West Nile virus transmission in a global context.

Authors:  Shlomit Paz
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-04-05       Impact factor: 6.237

7.  Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection.

Authors:  Sumit K Matta; Philipp Olias; Zhou Huang; Qiuling Wang; Eugene Park; Wayne M Yokoyama; L David Sibley
Journal:  Proc Natl Acad Sci U S A       Date:  2019-08-14       Impact factor: 11.205

8.  A Mouse Model of Zika Virus Pathogenesis.

Authors:  Helen M Lazear; Jennifer Govero; Amber M Smith; Derek J Platt; Estefania Fernandez; Jonathan J Miner; Michael S Diamond
Journal:  Cell Host Microbe       Date:  2016-04-05       Impact factor: 21.023

9.  Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection.

Authors:  Larissa B Thackray; Bimmi Shrestha; Justin M Richner; Jonathan J Miner; Amelia K Pinto; Helen M Lazear; Michael Gale; Michael S Diamond
Journal:  J Virol       Date:  2014-07-16       Impact factor: 5.103

10.  Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system.

Authors:  Helen M Lazear; Amelia K Pinto; Hilario J Ramos; Sarah C Vick; Bimmi Shrestha; Mehul S Suthar; Michael Gale; Michael S Diamond
Journal:  J Virol       Date:  2013-08-21       Impact factor: 5.103
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