OBJECTIVE: Examine the contribution of Nox1 NADPH oxidase to atherogenesis. METHODS AND RESULTS: Male apolipoprotein E deficient mice (ApoE(-/-)) and male mice deficient in both apolipoprotein E and Nox1 (ApoE(-/-) Nox1(-/y)) received an atherogenic diet for 18 weeks. Mean blood pressures, body weights, and serum cholesterol levels were similar between the two groups of mice. Deficiency of Nox1 decreased superoxide levels and reduced lesion area in the aortic arch from 43% (ApoE(-/-)) to 28% (ApoE(-/-) Nox1(-/y)). The reduction in lesion size at the level of the aortic valve in ApoE(-/-)/Nox1(-/y) was accompanied by a decrease in macrophage infiltration as compared to ApoE(-/-) mice. Carotid artery ligation in ApoE(-/-) mice induced accelerated intimal hyperplasia with decreased cellular proliferation and increased collagen content in the neointima of vessels deficient in Nox1. CONCLUSIONS: Nox1-derived ROS modify lesion composition and contribute to lesion size in a murine model of atherosclerosis. Published by Elsevier Ireland Ltd.
OBJECTIVE: Examine the contribution of Nox1NADPH oxidase to atherogenesis. METHODS AND RESULTS: Male apolipoprotein E deficient mice (ApoE(-/-)) and male mice deficient in both apolipoprotein E and Nox1 (ApoE(-/-) Nox1(-/y)) received an atherogenic diet for 18 weeks. Mean blood pressures, body weights, and serum cholesterol levels were similar between the two groups of mice. Deficiency of Nox1 decreased superoxide levels and reduced lesion area in the aortic arch from 43% (ApoE(-/-)) to 28% (ApoE(-/-) Nox1(-/y)). The reduction in lesion size at the level of the aortic valve in ApoE(-/-)/Nox1(-/y) was accompanied by a decrease in macrophage infiltration as compared to ApoE(-/-) mice. Carotid artery ligation in ApoE(-/-) mice induced accelerated intimal hyperplasia with decreased cellular proliferation and increased collagen content in the neointima of vessels deficient in Nox1. CONCLUSIONS:Nox1-derived ROS modify lesion composition and contribute to lesion size in a murine model of atherosclerosis. Published by Elsevier Ireland Ltd.
Authors: Tomasz J Guzik; Jerzy Sadowski; Bartlomiej Guzik; Andrew Jopek; Boguslaw Kapelak; Piotr Przybylowski; Karol Wierzbicki; Ryszard Korbut; David G Harrison; Keith M Channon Journal: Arterioscler Thromb Vasc Biol Date: 2005-11-17 Impact factor: 8.311
Authors: Alison C Cave; Alison C Brewer; Anilkumar Narayanapanicker; Robin Ray; David J Grieve; Simon Walker; Ajay M Shah Journal: Antioxid Redox Signal Date: 2006 May-Jun Impact factor: 8.401
Authors: Aleksandr E Vendrov; Nageswara R Madamanchi; Zeenat S Hakim; Mauricio Rojas; Marschall S Runge Journal: Circ Res Date: 2006-04-06 Impact factor: 17.367
Authors: Roza E Clempus; Dan Sorescu; Anna E Dikalova; Lily Pounkova; Patricia Jo; George P Sorescu; Harald H H Schmidt; Bernard Lassègue; Kathy K Griendling Journal: Arterioscler Thromb Vasc Biol Date: 2006-11-02 Impact factor: 8.311
Authors: Manesh Thomas; Dan Gavrila; Michael L McCormick; Francis J Miller; Alan Daugherty; Lisa A Cassis; Kevin C Dellsperger; Neal L Weintraub Journal: Circulation Date: 2006-07-24 Impact factor: 29.690
Authors: Anna Dikalova; Roza Clempus; Bernard Lassègue; Guangjie Cheng; James McCoy; Sergey Dikalov; Alejandra San Martin; Alicia Lyle; David S Weber; Daiana Weiss; W Robert Taylor; Harald H H W Schmidt; Gary K Owens; J David Lambeth; Kathy K Griendling Journal: Circulation Date: 2005-10-17 Impact factor: 29.690
Authors: Steven J Forrester; Daniel S Kikuchi; Marina S Hernandes; Qian Xu; Kathy K Griendling Journal: Circ Res Date: 2018-03-16 Impact factor: 17.367
Authors: Tamara Atkinson; William Packwood; Aris Xie; Sherry Liang; Yue Qi; Zaverio Ruggeri; Jose Lopez; Brian P Davidson; Jonathan R Lindner Journal: J Am Soc Echocardiogr Date: 2018-09-11 Impact factor: 5.251