| Literature DB >> 21410270 |
Marina Martjuga1, Sergey Belyakov, Edvards Liepinsh, Edgars Suna.
Abstract
Chiral, nonracemic o-aminobenzylamines were prepared in a highly diastereoselective reduction of atropisomeric N-tert-butanesulfinylketimines. The ortho-substituent ensures the distinct reactivity of atropisomers 4d-f. The free energy of activation for atropisomerization of sulfinylimines 4d-f in THF-d(8) was determined by NMR methods to range from 70.8 to 97.9 kJ/mol.Entities:
Year: 2011 PMID： 21410270 DOI： 10.1021/jo1025767
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354