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Literature DB >> 214074

Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay.

T R Skopek, H L Liber, B W Penman, W G Thilly.

Abstract

Entities: CellLine Species

Mesh：

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Year: 1978 PMID： 214074 DOI： 10.1016/0006-291x(78)90185-7

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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37 in total

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Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay.

1. Interchromosomal gene conversion at an endogenous human cell locus.

2. A rapid survival assay to measure drug-induced cytotoxicity and cell cycle effects.

3. Delivery method, target gene structure, and growth properties of target cells impact mutagenic responses to reactive nitrogen and oxygen species.

4. A system for exposing molecules and cells to biologically relevant and accurately controlled steady-state concentrations of nitric oxide and oxygen.

5. American ginseng suppresses colitis through p53-mediated apoptosis of inflammatory cells.

6. Mutational spectrometry: a general approach for hot-spot point mutations in selectable genes.

7. Mitochondrial mutational spectra in human cells and tissues.

8. Mutational spectrometry without phenotypic selection: human mitochondrial DNA.

9. Fidelity and mutational spectrum of Pfu DNA polymerase on a human mitochondrial DNA sequence.

10. Both PIGA and PIGL mutations cause GPI-a deficient isolates in the Tk6 cell line.