| Literature DB >> 21406545 |
Stephen Harding1, Francois Provot, Jean-Baptise Beuscart, Mark Cook, Arthur R Bradwell, Stephanie Stringer, Darren White, Paul Cockwell, Colin A Hutchison.
Abstract
Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.Entities:
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Year: 2011 PMID： 21406545 DOI： 10.1093/ndt/gfr019
Source DB: PubMed Journal: Nephrol Dial Transplant ISSN： 0931-0509 Impact factor: 5.992