OBJECTIVE: Previous research has shown that dopamine signaling in the limbic striatum is crucial for selecting adaptive, motivated behavior and that disrupted dopamine transmission is associated with impulsive and maladaptive behavior. In humans, positron emission tomography (PET) imaging studies have shown that cocaine dependence is associated with the dysregulation of striatal dopamine signaling, which is linked to cocaine-seeking behavior. The goal of the present study was to investigate whether this association applies to the treatment setting. The authors hypothesized that dopamine signaling in the limbic striatum would be associated with response to a behavioral treatment that uses positive reinforcement to replace impulsive cocaine use with constructive personal goals. METHOD: Prior to treatment, cocaine-dependent subjects underwent two PET scans using [(11)C]raclopride, before and after the administration of a stimulant (methylphenidate), for measurement of striatal dopamine D(2/3) receptor binding and presynaptic dopamine release. RESULTS: Both of the outcome measures were lower in the volunteers who did not respond to treatment than in those who experienced a positive treatment response. CONCLUSIONS: These findings provide insight into the neurochemistry of treatment response and show that low dopamine transmission is associated with treatment failure. In addition, these data suggest that the combination of behavioral treatment with methods that increase striatal dopamine signaling might serve as a therapeutic strategy for cocaine dependence.
OBJECTIVE: Previous research has shown that dopamine signaling in the limbic striatum is crucial for selecting adaptive, motivated behavior and that disrupted dopamine transmission is associated with impulsive and maladaptive behavior. In humans, positron emission tomography (PET) imaging studies have shown that cocaine dependence is associated with the dysregulation of striatal dopamine signaling, which is linked to cocaine-seeking behavior. The goal of the present study was to investigate whether this association applies to the treatment setting. The authors hypothesized that dopamine signaling in the limbic striatum would be associated with response to a behavioral treatment that uses positive reinforcement to replace impulsivecocaine use with constructive personal goals. METHOD: Prior to treatment, cocaine-dependent subjects underwent two PET scans using [(11)C]raclopride, before and after the administration of a stimulant (methylphenidate), for measurement of striatal dopamine D(2/3) receptor binding and presynaptic dopamine release. RESULTS: Both of the outcome measures were lower in the volunteers who did not respond to treatment than in those who experienced a positive treatment response. CONCLUSIONS: These findings provide insight into the neurochemistry of treatment response and show that low dopamine transmission is associated with treatment failure. In addition, these data suggest that the combination of behavioral treatment with methods that increase striatal dopamine signaling might serve as a therapeutic strategy for cocaine dependence.
Authors: A Breier; T P Su; R Saunders; R E Carson; B S Kolachana; A de Bartolomeis; D R Weinberger; N Weisenfeld; A K Malhotra; W C Eckelman; D Pickar Journal: Proc Natl Acad Sci U S A Date: 1997-03-18 Impact factor: 11.205
Authors: N D Volkow; G J Wang; J S Fowler; J Logan; S J Gatley; R Hitzemann; A D Chen; S L Dewey; N Pappas Journal: Nature Date: 1997-04-24 Impact factor: 49.962
Authors: N D Volkow; G J Wang; J S Fowler; J Logan; D Schlyer; R Hitzemann; J Lieberman; B Angrist; N Pappas; R MacGregor Journal: Synapse Date: 1994-04 Impact factor: 2.562
Authors: Diana Martinez; Allegra Broft; Richard W Foltin; Mark Slifstein; Dah-Ren Hwang; Yiyun Huang; Audrey Perez; W Gordon Frankle; Thomas Cooper; Herbert D Kleber; Marian W Fischman; Marc Laruelle; W Gordon Frankel Journal: Neuropsychopharmacology Date: 2004-06 Impact factor: 7.853
Authors: Sarah W Yip; Elise E DeVito; Hedy Kober; Patrick D Worhunsky; Kathleen M Carroll; Marc N Potenza Journal: Drug Alcohol Depend Date: 2016-07-16 Impact factor: 4.492
Authors: Isabelle Boileau; Doris Payer; Sylvain Houle; Arian Behzadi; Pablo M Rusjan; Junchao Tong; Diana Wilkins; Peter Selby; Tony P George; Martin Zack; Yoshiaki Furukawa; Tina McCluskey; Alan A Wilson; Stephen J Kish Journal: J Neurosci Date: 2012-01-25 Impact factor: 6.167
Authors: Isabelle Boileau; Doris Payer; Pablo M Rusjan; Sylvain Houle; Junchao Tong; Tina McCluskey; Alan A Wilson; Stephen J Kish Journal: Neuropsychopharmacology Date: 2016-06-29 Impact factor: 7.853
Authors: I Boileau; D Payer; B Chugani; D S S Lobo; S Houle; A A Wilson; J Warsh; S J Kish; M Zack Journal: Mol Psychiatry Date: 2013-12-10 Impact factor: 15.992
Authors: Rajesh Narendran; Savannah Tollefson; Michael L Himes; Jennifer Paris; Brian Lopresti; Roberto Ciccocioppo; N Scott Mason Journal: Am J Psychiatry Date: 2019-05-06 Impact factor: 18.112