Literature DB >> 2140628

Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent.

B Vanhaesebroeck1, H T Timmers, G J Pronk, F van Roy, A J Van der Eb, W Fiers.   

Abstract

Primary baby rat kidney cells, primary human embryonic retinoblast cells, established NIH3T3 and established normal rat kidney (NRK) cells, expressing E1A and/or E1B gene regions of adenovirus 5 (Ad5) or Ad12, were investigated for susceptibility to the cytotoxic/cytostatic action of Tumor Necrosis Factor (TNF). In the primary cells and in the NRK cells, there was no correlation between TNF sensitivity and E1 gene expression; neither did sensitivity to TNF correlate with the oncogenicity of the Ad serotype. In contrast, the expression of Ad E1 gene regions in NIH3T3 cells was found to enhance TNF sensitivity of this cell line. Differences in E1A expression levels between cell types cannot explain this discrepancy regarding modulation of TNF sensitivity by E1A.

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Year:  1990        PMID： 2140628     DOI： 10.1016/0042-6822(90)90006-d

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  8 in total

1.  Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins.

Authors:  E White; R Cipriani; P Sabbatini; A Denton
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

2.  The adenovirus E3-14.7K protein and the E3-10.4K/14.5K complex of proteins, which independently inhibit tumor necrosis factor (TNF)-induced apoptosis, also independently inhibit TNF-induced release of arachidonic acid.

Authors:  P Krajcsi; T Dimitrov; T W Hermiston; A E Tollefson; T S Ranheim; S B Vande Pol; A H Stephenson; W S Wold
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

3.  Role of the E1A Rb-binding domain in repression of the NF-kappa B-dependent defense against tumor necrosis factor-alpha.

Authors:  James L Cook; Thomas A Walker; G Scott Worthen; Jay R Radke
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-15       Impact factor: 11.205

4.  The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells.

Authors:  L R Gooding; L Aquino; P J Duerksen-Hughes; D Day; T M Horton; S P Yei; W S Wold
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

5.  The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cells.

Authors:  P J Duerksen-Hughes; T W Hermiston; W S Wold; L R Gooding
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

6.  The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.

Authors:  E White; P Sabbatini; M Debbas; W S Wold; D I Kusher; L R Gooding
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

7.  The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor.

Authors:  L R Gooding; T S Ranheim; A E Tollefson; L Aquino; P Duerksen-Hughes; T M Horton; W S Wold
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

8.  Antioncogenic effect of adenovirus E1A in human tumor cells.

Authors:  S M Frisch
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205
  8 in total

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