Literature DB >> 21406172

Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions.

Toni A Nagy1, Shannon S Allen, Lydia E Wroblewski, David K Flaherty, James C Slaughter, Guillermo Perez-Perez, Dawn A Israel, Richard M Peek.   

Abstract

The host immune response directed against Helicobacter pylori is ineffective in eliminating the organism and strains harboring the cag pathogenicity island augment disease risk. Because eosinophils are a prominent component of H. pylori-induced gastritis, we investigated microbial and host mechanisms through which H. pylori regulates eosinophil migration. Our results indicate that H. pylori increases production of the chemokines CCL2, CCL5, and granulocyte-macrophage colony-stimulating factor by gastric epithelial cells and that these molecules induce eosinophil migration. These events are mediated by the cag pathogenicity island and by mitogen-activated protein kinases, suggesting that eosinophil migration orchestrated by H. pylori is regulated by a virulence-related locus.
Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21406172      PMCID： PMC3078468          DOI： 10.1016/j.ajpath.2010.12.018

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  14 in total

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Review 2.  Helicobacter pylori and gastrointestinal tract adenocarcinomas.

Authors:  Richard M Peek; Martin J Blaser
Journal:  Nat Rev Cancer       Date:  2002-01       Impact factor: 60.716

3.  The role of mast cells and eosinophils in chronic gastritis.

Authors:  N Moorchung; A N Srivastava; N K Gupta; A K Malaviya; B R Achyut; B Mittal
Journal:  Clin Exp Med       Date:  2006-10       Impact factor: 3.984

4.  Eosinophil infiltration and degranulation in Helicobacter pylori-associated chronic gastritis.

Authors:  T W McGovern; N J Talley; G M Kephart; H A Carpenter; G J Gleich
Journal:  Dig Dis Sci       Date:  1991-04       Impact factor: 3.199

5.  Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island.

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Journal:  Nat Immunol       Date:  2004-10-17       Impact factor: 25.606

6.  Functional association between the Helicobacter pylori virulence factors VacA and CagA.

Authors:  Richard H Argent; Rachael J Thomas; Darren P Letley; Michael G Rittig; Kim R Hardie; John C Atherton
Journal:  J Med Microbiol       Date:  2008-02       Impact factor: 2.472

7.  Helicobacter pylori and mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells.

Authors:  Song-Ze Ding; Igor N Olekhnovich; Timothy L Cover; Richard M Peek; Michael F Smith; Joanna B Goldberg
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Authors:  Daniel P O'Brien; Judith Romero-Gallo; Barbara G Schneider; Rupesh Chaturvedi; Alberto Delgado; Elizabeth J Harris; Uma Krishna; Seth R Ogden; Dawn A Israel; Keith T Wilson; Richard M Peek
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9.  Helicobacter exploits integrin for type IV secretion and kinase activation.

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Review 10.  The role of myeloid cells in the promotion of tumour angiogenesis.

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Journal:  Nat Rev Cancer       Date:  2008-07-17       Impact factor: 60.716
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  7 in total

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Journal:  Sci Rep       Date:  2015-03-04       Impact factor: 4.379

5.  Helicobacter pylori outer membrane vesicle proteins induce human eosinophil degranulation via a β2 Integrin CD11/CD18- and ICAM-1-dependent mechanism.

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Journal:  Mediators Inflamm       Date:  2015-03-04       Impact factor: 4.711

Review 6.  Helicobacter Pylori and Autoimmune Diseases: Involving Multiple Systems.

Authors:  Li Wang; Zheng-Min Cao; Li-Li Zhang; Xin-Can Dai; Zhen-Ju Liu; Yi-Xian Zeng; Xin-Ye Li; Qing-Juan Wu; Wen-Liang Lv
Journal:  Front Immunol       Date:  2022-02-10       Impact factor: 7.561

7.  Human gastric epithelial cells contribute to gastric immune regulation by providing retinoic acid to dendritic cells.

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  7 in total

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